摘要
目的观察艾司西酞普兰联合奥氮平治疗难治性抑郁症的临床效果。方法将70例难治性抑郁症患者随机分为观察组与对照组,每组35例。对照组患者采用艾司西酞普兰治疗,观察组患者采用艾司西酞普兰联合奥氮平治疗。观察两组患者不同治疗时间节点汉密顿抑郁量表(Hamilton Depression Scale,HAMD)评分变化情况、睡眠质量改善情况及临床治疗效果。结果两组患者治疗前HAMD评分接近(P>0.05),两组患者治疗后不同时间节点HAMD评分均较治疗前降低,观察组患者降幅更加显著,组间比差异具统计学意义(P<0.05)。观察组患者的治疗有效率显著高于对照组患者,组间比差异具统计学意义(P<0.05)。两组患者治疗前PSQI评分无差异,(P>0.05),两组患者治疗后PSQI评分均较治疗前降低,观察组患者降幅更加显著,组间比差异具统计学意义(P<0.05)。结论难治性抑郁症患者临床应用艾司西酞普兰联合奥氮平治疗,显著降低患者的HAMD评分,临床疗效确切,值得临床广泛推广应用。
Objective:To observe the clinical effect of escitalopram combined with olanzapine in the treatment of refractory depression.Methods:70 patients with refractory depression were randomly divided into observation group and control group,35 cases in each group.Patients in the control group were treated with escitalopram,while those in the observation group were treated with escitalopram combined with olanzapine.The changes of Hamilton Depression Scale(HAMD)score,improvement of sleep quality and clinical treatment effect were observed in the two groups at different treatment time points.Results:HAMD scores of the two groups were close to each other before treatment(P>0.05),and HAMD scores of the two groups were lower at different time points after treatment than before treatment.The decrease was more significant in the observation group,and the difference between the two groups was statistically significant(P<0.05).The treatment efficiency of the observation group was significantly higher than that of the control group,and the difference between groups was statistically significant(P<0.05).There was no difference in PSQI score between the two groups before treatment(P>0.05).PSQI score of the two groups after treatment was lower than that before treatment,and the decrease was more significant in the observation group(P<0.05).Conclusion:The clinical application of escitalopram combined with olanzapine in the treatment of refractory depression can significantly reduce the HAMD score of patients,and the clinical efficacy is definite,which is worthy of extensive clinical application.
作者
王婷婷
高兰
崔付新
张清清
WANG Ting-ting;GAO Lan;CUI Fu-xin;ZHANG Qing-qing(Linyi Mental Health Center,Linyi 276002,China)
出处
《泰山医学院学报》
CAS
2019年第12期917-919,共3页
Journal of Taishan Medical College
关键词
艾司西酞普兰
奥氮平
难治性抑郁症
临床疗效
escitalopram
Olanzapine
refractory depression
clinical curative effect
