摘要
目的:观察阿托伐他汀治疗脑梗死合并动脉硬化患者的效果。方法:选取80例脑梗死合并动脉硬化患者为研究对象,采用随机数字表法分为观察组(42例)和对照组(38例)。对照组予常规治疗,观察组在对照组基础上予阿托伐他汀治疗,比较两组患者炎性因子、抗氧化指标水平、动脉粥样硬化程度、神经功能及不良反应发生率。结果:治疗前及治疗后1个月两组间炎性因子水平、抗氧化指标水平、颈动脉内中膜厚度及斑块面积比较,差异均无统计学意义(P>0.05);治疗后6个月,观察组白细胞介素、肿瘤坏死因子、C反应蛋白水平、丙二醛水平、颈动脉内中膜厚度及斑块面积均低于或小于对照组,超氧化物歧化酶和谷胱甘肽过氧化物酶水平均高于对照组,差异均有统计学意义(P<0.05)。两组脑卒中量表评分均较治疗前降低,且观察组低于对照组,差异均有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:在常规治疗基础上采用阿托伐他汀治疗脑梗死合并动脉粥样硬化患者,能有效降低炎性因子和抗氧化指标水平,延缓动脉粥样硬化进程。
Objective:To observe effects of Atorvastatin in patients with cerebral infarction and arteriosclerosis.Methods:80 patients with cerebral infarction and arteriosclerosis were enrolled in the study.They were divided into observation group(42 cases)and control group(38 cases)according to the random number table method.The control group received conventional treatment,while the observation group was treated with Atorvastatin on the basis of that of the control group.The inflammatory factors and antioxidant index levels,degree of atherosclerosis,neurological function and adverse reactions were compared between the two groups.Results:There were no significant differences in the inflammatory factor levels,antioxidant index levels,and carotid intima-media thickness between the two groups before and 1 month after the treatment(P>0.05).6 months after the treatment,the levels of interleukin,tumor necrosis factor,C-reactive protein,malondialdehyde as well as carotid intima-media thickness and plaque area were lower in the observation group than those in the control group,the levels of superoxide dismutase glutathione peroxidase were higher than those in the control group,and the differences were statistically significant(P<0.05).The scores of the stroke scale of the two groups after the treatment were lower than those before the treatment,that of the observation group was lower than that of the control group,the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:On the basis of the conventional treatment,Atorvastatin can effectively reduce the levels of inflammatory factors and antioxidant indexes in the patients with cerebral infarction and atherosclerosis.Moreover,its effect on delaying the process of atherosclerosis is better than that of the conventional treatment.
作者
董蕾蕾
DONG Leilei(Department of Neurology of the Second Affiliated Hospital of Shenyang Medical College,Shenyang 110000 Liaoning,China)
出处
《中国民康医学》
2019年第20期9-11,共3页
Medical Journal of Chinese People’s Health
关键词
脑梗死
动脉硬化
阿托伐他汀
临床疗效
Cerebral infarction
Arteriosclerosis
Atorvastatin
Clinical efficacy
