摘要
目的探讨阿司匹林联合氯吡格雷治疗对无症状脑梗死(ACI)患者神经功能和日常生活能力的影响。方法 82例ACI患者随机分为两组各41例,对照组采用阿司匹林肠溶片治疗,观察组采用阿司匹林肠溶片联合氯吡格雷治疗。比较两组的临床疗效、蒙特利尔认知评估量表(MoCA)评分、生活质量评定量表评分及不良反应。结果观察组的治疗总有效率为90.24%,显著高于对照组的73.17%(P<0.05)。治疗后,两组患者的MoCA评分、生活质量评分均显著高于治疗前(P均<0.05),且观察组的MoCA评分、生活质量评分均显著高于对照组(P均<0.05)。两组的不良反应发生率比较,差异无统计学意义(P>0.05)。结论阿司匹林联合氯吡格雷治疗无症状脑梗死的效果显著,可明显改善患者的神经功能和日常生活能力,且安全性较高。
Objective To explore the effects of aspirin combined with clopidogrel treatment on the neurological function and ability of daily living in patients with asymptomatic cerebral infarction(ACI). Methods 82 ACI patients were randomly divided into two groups,with 41 cases in each group. The control group was treated with aspirin enteric-coated tablets, and the observation group was treated with aspirin enteric-coated tablets combined with clopidogrel. The clinical efficacy, score of Montreal cognitive assessment scale(MoCA), score of quality of life assessment scale and adverse reactions were compared between two groups. Results The total effective rate of treatment of observation group was 90.24%, significantly higher than 73.17% of control group(P<0.05). After treatment, the MoCA score and quality of life score of both groups were significantly higher than those before treatment(P<0.05), and the MoCA score and quality of life score of observation group were significantly higher than those of control group(P<0.05). No significant difference was found in the incidence of adverse reactions between two groups(P>0.05). Conclusions Aspirin combined with clopidogrel in the treatment of asymptomatic cerebral infarction has significant effect and high safety, which can obviously improve patients’ neurological function and ability of daily living.
作者
林键恒
欧列斌
刘婷
LIN Jianheng;OU Liebin;LIU Ting(1st Ward of Brain Department,Chancheng District Central Hospital,Foshan 528000,China)
出处
《临床医学工程》
2019年第12期1663-1664,共2页
Clinical Medicine & Engineering
关键词
阿司匹林
氯吡格雷
无症状脑梗死
神经功能
日常生活能力
Aspirin
Clopidogrel
Asymptomatic cerebral infarction(ACI)
Neurological function
Ability of daily living
