摘要
目的探讨盐酸吡格列酮胶囊联合缬沙坦胶囊对代谢综合征患者血压水平及胰岛素抵抗的影响。方法选取代谢综合征患者120例,随机分为两组各60例。对照组采用缬沙坦胶囊及二甲双胍治疗,观察组采用缬沙坦胶囊联合盐酸吡格列酮胶囊治疗,比较两组的血压、血糖、胰岛素抵抗及不良反应。结果治疗后,观察组的SBP、DBP、FPG、2hPG、HbA1c、FINS及HOMA-IR均显著低于对照组(P<0.05)。两组的不良反应发生率无统计学差异(P>0.05)。结论盐酸吡格列酮胶囊联合缬沙坦胶囊治疗代谢综合征的效果显著、安全性高,可有效降低患者的血压水平,控制血糖代谢,改善胰岛素抵抗。
Objective To explore the effects of pioglitazone hydrochloride capsule combined with valsartan capsule on the blood pressure level and insulin resistance in patients with metabolic syndrome. Methods 120 patients with metabolic syndrome were selected and randomly divided into two groups, with 60 cases in each group. The control group was treated with valsartan capsule and metformin, while the observation group was treated with valsartan capsule combined with pioglitazone hydrochloride capsule. The blood pressure, blood sugar, insulin resistance and adverse reactions were compared between the two groups. Results After treatment, the SBP, DBP, FPG, 2 hPG,Hb A1 c, FINS and HOMA-IR of the observation group were significantly lower than those of the control group(P<0.05). No significant difference was found in the incidence of adverse reactions between the two groups(P>0.05). Conclusions Pioglitazone hydrochloride capsule combined with valsartan capsule for the treatment of metabolic syndrome has significant effect and high safety, which can effectively reduce the blood pressure level, control the blood glucose metabolism and improve insulin resistance of patients.
作者
衷锐
骆晓敏
姚娟丽
周立尧
ZHONG Rui;LUO Xiaomin;YAO Juanli;ZHOU Liyao(Beijiao Hospital of Shunde District,Foshan 528311,China)
出处
《临床医学工程》
2019年第12期1675-1676,共2页
Clinical Medicine & Engineering
关键词
代谢综合征
盐酸吡格列酮胶囊
缬沙坦胶囊
血压
胰岛素抵抗
Metabolic syndrome
Pioglitazone hydrochloride capsule
Valsartan capsule
Blood pressure
Insulin resistance
