MHR与老年2型糖尿病合并颈动脉粥样斑块的相关性研究被引量：4

Correlation between MHR and carotid atherosclerosis in elderly patients with type 2 diabetes mellitus

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摘要目的研究2型糖尿病(T2DM)的老年患者中单核细胞数和高密度脂蛋白胆固醇比值(MHR)与颈动脉粥样斑块(CAS)的相关性。方法收集老年2型糖尿病患者132例,其中糖尿病并颈动脉粥样硬化斑块(A组)73例,未合并颈动脉粥样硬化斑块(B组)59例。记录患者的化验指标及影像检查结果,并进行组间比较,探讨T2DM的老年患者发生颈动脉粥样斑块的影响因素。结果A组年龄、高血压患病率、SBP、HbA1c、FPG、MHR高于B组,差异有统计学意义(均P<0.05)。通过多因素Logistic回归分析,年龄、HbA1c、FPG、MHR是老年2型糖尿病并CAS的相关危险因素,HDL-C是老年2型糖尿病合并CAS的保护因素。ROC绘制MHR下的面积为0.835(95%CI:0.768~0.902,P<0.01)。当MHR=0.547其诊疗效率最高,敏感性为75%,特异性为80%。结论MHR是老年T2DM合并颈动脉斑块的相关危险因素之一且具有预估价值。 Objective To study the correlation between mononuclear cells and high-density lipoprotein ratio(MHR)and carotid atherosclerosis in elderly patients with type 2 diabetes mellitus.Methods One hundred and thirty two patients with type 2 diabetes were collected,of which there were 73 cases of diabetes and carotid atherosclerotic plaque(group A),and 59 cases were not combined with carotid atherosclerotic plaques(group B).The results of test and image examination of patients with T2DM were recorded,and the influencing factors of carotid atherosclerosis in aged patients with T2DM were discussed.Results Age,prevalence of hypertension and SBP,HbA1c,FPG,MHR in group A were significantly higher than those in group B(all P<0.05).By multivariate Logistic regression analysis,age and HbA1c,FPG,MHR were the risk factors of elderly type 2 diabetes mellitus complicated with CAS,and HDL-C was the protective factor of elderly type 2 diabetes mellitus complicated with CAS.The area under MHR drawn by ROC was 0.835(95%CI:0.768~0.902,P<0.01).When MHR=0.547 was the most effective,the sensitivity was 75%and the specificity was 80%.Conclusion MHR is one of the risk factors in elderly T2DM complicated with carotid plaques.

作者薛舒红朱婷李华李伟芳 XUE Shu-hong;ZHU Ting;LI Hua;LI Wei-fang(Department of elderly Endocrinology,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)

机构地区郑州大学第一附属医院老年内分泌科

出处《河南医学研究》 CAS 2019年第24期4436-4438,共3页 Henan Medical Research

关键词 2型糖尿病颈动脉粥样硬化老年人单核细胞与高密度脂蛋白胆固醇比值 type 2 diabetes mellitus carotid atherosclerosis the aged monocyte-to-high density lipoprotein cholesterol ratio

分类号 R587.2 [医药卫生—内分泌]

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1汪会琴,胡如英,武海滨,俞敏.2型糖尿病报告发病率研究进展[J].浙江预防医学,2016,28(1):37-39. 被引量：365

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