摘要
目的:探讨BPPV疾病的家族遗传性,以期未来能够指导临床,起到及早预防以及缩短病程的目的。方法:对家族性BPPV详细询问并登记病史特征,包括每个家族中发病患者的性别、初次发病年龄、职业、有无诱发因素、症状、诊断、睡眠状况、临床表现等。对临床相关资料进行分析。结果:9例来源于4个家系的原发性BPPV患者,全部无明确致病因素;其中男3例,女6例;初次发病年龄31~66岁;病程2 d^8年。眼震持续时间为数秒至1 min;临床症状主要表现为与体位变换有关的头晕、视物旋转。家系1、3、4中发病患者多有发病前疲劳史,家系2中2例患者有因为腰部不适强迫侧卧位的前驱因素。所有患者的眼震持续时间均小于1 min,均为单管受累,管石型耳石症。同一个家族中的不同患者发病位置可不一致。结论:家族性BPPV患者迫切需要引起临床医生以及公众的重视。对可疑家族性BPPV患者提前进行临床筛查可以起到及早预防以及缩短病程的目的,进而提高患者的生活质量。
Objective: The family heredity of BPPV disease was preliminarily discussed in order to guide the clinical practice, prevent early and shorten the course of BPPV disease in the future. Method: Familial BPPV patients were enquired and registered in detail, including gender, age at first onset, occupation, inducing factors, symptoms, diagnosis, sleep status and clinical manifestations. Analysis of the clinical data. Result: Nine patients with idiopathic BPPV from four families had no definite pathogenic factors, accounting for 0.4% of the patients with idiopathic BPPV, including 3 males and 6 females;the age of first onset ranged from 31 to 66 years old. the course of disease ranged from 2 days to 8 years;the duration of nystagmus ranged from seconds to 1 minute. The main clinical symptoms were dizziness and visual rotation related to position transformation. Family 1, 3 and 4 patients had a history of fatigue. Family 2 patients had a predisposing factor of forced lateral decubitus due to lumbar discomfort. All patients had nystagmus lasting less than 1 minute and were single-tube involvement, all patients were canalithiasis. Different patients in the same family have different pathogenic locations. Conclusion: Familial BPPV is urgent to attract the attention of clinicians and the public. Early clinical test for suspected familial BPPV can play a role in early prevention and shorten the process of disease, so as to improve the life quality of patients.
作者
王倩
袁宝明
金鹏
毛婷婷
庞月
于红
WANG Qian;YUAN Baoming;JIN Peng;MAO Tingling;PANG Yue;YU Hong(Department of Otolaryngology,the First Hospital of Jilin University,Changchun,130000,China;Department of Otolaryngology,the Second Hospital o£Jilin University)
出处
《临床耳鼻咽喉头颈外科杂志》
CAS
北大核心
2019年第11期1095-1098,共4页
Journal of Clinical Otorhinolaryngology Head And Neck Surgery
基金
吉林省科技发展计划项目(No:20190304123YY)
关键词
良性阵发性位置性眩晕
家系
临床特点
benign paroxysmal positional vertigo
family
clinical features
