摘要
目的 通过对云南省农村地区育龄妇女孕前血清促甲状腺激素(TSH)的检测,筛查出云南省育龄妇女甲状腺疾病高发区及高发人群,为孕前优生提供重要参考依据,减少不孕不育和不良妊娠结局的发生.方法 利用西门子ADVIA Centuar XP全自动化学发光仪及进口配套试剂对来源于云南省16个地区,16个民族的30163例农村育龄妇女(20~49岁)空腹血血清促甲状腺激素(TSH)进行检测.结果 经检测后发现血清TSH异常的有1797例,异常率为5.96%.其中TSH减低人群占比为3.09%;TSH升高人群占比为2.87%.且不同地区、不同民族的育龄妇女血清TSH的异常率存在一定差异.在筛查的16个地区中,血清TSH异常率最高的为西盟县(8.90%),最低的为迪庆州(3.60%);在筛查的15个少数民族中,血清TSH异常率最高的为傈僳族(9.73%),最低的为藏族(3.60%).结论 民族和地区因素均可能会对育龄妇女的甲状腺疾病的患病情况产生一定影响,并且在同一地区或同一民族内,TSH减低和升高人群的比例同时较高的几率较小.
Objective Through screening the serum TSH in rural pregestational women,fo find out the high incidence area and high risk population of thyroid disease in Yunnan province,to reduce the probability of infertility and abnormal pregnancy and provide important reference basis for prenatal aristogenesis.Methods The serum TSH level of 30163 rural pregestational women(20-49 yeas old)which from 16 different areas and 16 different ethnicities of Yunnan province was detected by using TSH3-Ultra(TSH3-UL)reagent on a Siemens centar-XP automatic chemiluminescence apparatus.Results 1797 women were found with abnormal serum TSH level,the abnormal rate was 5.96%.Among them,the proportion of women with decreased TSH was 3.09%and increased TSH was 2.87%,compared with the normal reference range.And there was a significant difference of abnormal serum TSH rate between pregestational women from different areas and ethnicities.Moreover,in the 16 tested areas,the highest abnormal serum TSH rate was 8.90%from Ximeng county,the lowest was 3.60%from Diqing state.However in the 16 tested ethnicities,the highest abnormal serum TSH rate was 9.73%from Lisu ethnic minority and the lowest was 3.60%from Tibetan ethnic minority.Conclusions The results inferred that ethnic and regional factors both to some extent affect the prevalence of thyroid disease in pregestational women and it is a small probability event that high occurrence of TSH decreased or increased situation simultaneously happened in one area or one ethnicity.
作者
谢正媛
李根瑞
陈涓涓
孙虹
曹光
Xie Zhengyuan;Li Genrui;Chen Juanjuan;Sun Hong;Cao Guang(Key Laboratory for Fertility Regulation and Minority Birth Health Research of Yunnan Province,Key Laboratory of Preconception Health in Western China,NHFPC,Population and Family Planning Institute of Yunnan Province,Kunming 650021,China;Key Laboratory of Medicinal Chemistry for Natural Resources,Ministry of Education and Yunnan Province,School of Chemical Science and Technology,Yunnan University,Kunming 650091,China)
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
2019年第11期962-968,共7页
Chinese Journal of Endocrinology and Metabolism
基金
国家卫生健康委员会重点实验室开放项目(ZDsys2016003)
云南省重点实验室开放项目(Zdsys2013001)。
关键词
促甲状腺激素
育龄妇女
农村地区
云南少数民族
Thyroid stimulating hormone
Pregestational Women
Rural areas
Minority of Yunnan Province
