摘要
目的探讨谷氨酰转肽酶(GGT)、高尔基体糖蛋白73(GP73)、甲胎蛋白(AFP)联合诊断早期原发性肝癌的价值.方法收集2015年9月~2016年9月我院收治的36例原发性肝癌患者,选择同时期我院收治的肝硬化患者40例作为对照1组、健康体检的40例人员作为对照组2组,比较三组人员GGT、GP73、AFP检测情况.结果①观察组AFP水平(975.8±16.2)ng/ml、GP73水平(228.0±15.9)ng/ml、GGT水平(19.9±4.2)ng/ml显著高于对照1组、对照组2组水平,组间比较差异具有统计学意义(P<0.05).对照组1组、对照组2组GGT、GP73、AFP水平无显著差异(P>0.05).②观察组AFP阳性率75.0%、GP73阳性率70.0%、GGT阳性率62.5%、三者联合阳性率87.5%显著高于对照1组、对照组2组水平,三者联合阳性检测率均显著高于各单一指标检测结果,组间比较差异具有统计学意义(P<0.05).对照组1组GGT、GP73、AFP及三者联合阳性率显著高于对照2组,组间比较差异具有统计学意义(P<0.05).结论联合应用GGT、GP73、AFP有助于提高早期原发性肝癌的诊断准确率.
Objective To investigate the value of combination of glutamyl glutamyl peptidase(GGT),Golgi glycoprotein 73(GP73)and alpha fetoprotein(A FP)in the diagnosis of early primary liver cancer.Methods 36 cases collected from September 2015~2016 year in September in our hospital in patients with primary liver cancer,40 cases of choice during the same period in our hospital 40 cases of cirrhosis patients as control group,1 healthy as control group 2 group,GGT,GP73,AFP compared three groups of staff.Results the AFP level of the observation group(975.8+16.2)ng/ml,GP73(228+15.9)ng/ml,GGT(19.9+4.2)ng/ml was significantly higher than that of control group 1 and control group 2,the difference was statistically significant(P<0.05).There was no significant difference in the levels of GGT,GP73 and AFP between the 2 groups and the control group(P>0.05)in the control group,1 groups and the control group.The observation group AFP positive rate was 75%,the positive rate of GP73 was 70%,GGT positive rate was 62.5%,three and the positive rate was 87.5%significantly higher than the control group 1,control group 2 group level,the combination of the three positive detection rate was significantly higher than the test results of each single index,the difference between groups was statistically significant(P<0.05).In the control group,the positive rate of GGT,G P73,AFP and three groups was significantly higher than that of the control group,the difference between the 2 groups was statistically significant(P<0.05);the difference between the two groups was statistically significant.Conclusion Combined application of GGT,GP73 and AFP is helpful to improve the accuracy of early diagnosis of primary liver cancer.
作者
粟劲松
丁佑铭
Su Jin-song;DING You-ming(Hepatobiliary surgery,Renmin Hospital of Wuhan University,Wuhan,Hubei 430060,China)
出处
《肝胆外科杂志》
2019年第5期352-355,共4页
Journal of Hepatobiliary Surgery
基金
武汉市科学技术攻关项目(201260523178-6)。
