摘要
目的:探讨通乳络方对气血两虚型产后缺乳患者的疗效及催乳素的影响。方法:气血两虚型产后缺乳患者66例,随机分两组,各33例,对照组采用缩宫素注射液0.5~2单位肌肉注射;观察组采用通乳络方治疗,每日1剂,持续治疗7 d。比较两组患者临床疗效、中医证候积分及血泌乳素(Prolactin,PRL)、雌二醇(Estradiol,E2),记录不良反应。结果:对照组有效率75.76%低于观察组93.94%,差异具有统计学意义(P<0.05)。治疗前两组患者中医证候积分及血PRL、E2比较,差异无统计学意义(P>0.05)。治疗后对照组和观察组产后乳少评分为(1.31±0.56)、(0.68±0.42),乳房柔软评分为(1.20±0.51)、(0.61±0.37),面色无华评分为(1.31±0.56)、(0.46±0.31),神倦食少评分为(1.06±0.49)、(0.42±0.29),血PRL为(331.91±101.02)μg/L、(448.72±116.79)μg/L,血E2为(71.92±24.58)pg/mL、(54.39±20.21)pg/mL,对照组和观察组上述指标比较,差异具有统计学意义(P<0.05)。对照组出现2例恶心呕吐,2例胃部不适,对症处理后消失;观察组未见不良反应。结论:通乳络方对气血两虚型产后缺乳患者的疗效显著,可以提高催乳素、降低雌二醇,改善中医证候,且安全性高,值得推广。
Objective: To investigate the effect of Tongruluo Decoction in the treatment of patients with postpartum hypogalactia of type of Qi-blood deficiency on serum mammotrophic hormone. Methods:Sixty-six cases of postpartum hypogalactia of type of Qi-blood deficiency were randomly divided into two groups, 33 cases in each group. The control group received Oxytocin Injection 0.5-2 unitintramuscular injection, and the treatment group received Tongruluo Decoction once a day and two groups were treated for 7 days. The clinical efficacy, TCM syndrome score, blood prolactin(PRL), estradiol(E2) and adverse reactions were compared between the two groups. Results: The effective rate of the control group 75.76% was lower thanthe treatment group’s(93.94%) and the difference was statistically significant(P<0.05). There was no significant difference in TCM syndrome score, PRL or E2 between the two groups before treatment(P>0.05). Scores of postpartum milk deficiency in the control group and the treatment group were 1.31±0.56 and 0.68±0.42, breast softness were 1.20±0.51 and 0.61±0.37, facial complexion scores were 1.31±0.56 and 0.46±0.31, fatigue and food deficiency scores were1.06±0.49 and 0.42±0.29, levels of PRL were(331.91±101.02)μg/L and(448.72±116.79)μg/L, serum E2levels were(71.92±24.58)pg/mL and(54.39±20.21)pg/mL. The difference between the control group and the treatment group wasstatistically significant(P<0.05).Two cases had nausea and vomiting and two cases gastric discomfort in the control group, which disappeared after symptomatic treatment, and there was no adverse reaction in the treatment group. Conclusion:Tongruluo Decoction is effective on treating postpartum hypogalactia type of Qi-blood deficiency. It can increase prolactin, decrease estradiol and improve TCM syndromes. It is safe and worthy of popularizing.
作者
刘胜春
赵学刚
祝佩芹
LIU Shengchun;ZHAO Xuegang;ZHU Peiqin(Hebei Hospital of Traditional Chinese Medicine,Shijiazhuang 050011,Hebei,China;Hebei Austrian Group Pharmaceutical Co.Ltd,Shijiazhuang 050700,Hebei,China)
出处
《中华中医药学刊》
CAS
北大核心
2019年第11期2751-2753,共3页
Chinese Archives of Traditional Chinese Medicine
基金
河北省中医药管理局科研计划项目(2011087)
关键词
通乳络方
气血两虚型产后缺乳
催乳素
雌二醇
Tongruluo decoction
deficiency of Qi and blood type of postpartum lactation
prolactin
estradiol
