摘要
白假丝酵母是临床常见的引起医院获得性感染的主要病原菌之一。生物膜的形成是白假丝酵母的重要致病因素,并可使其对药物的抵抗能力大大增强。白假丝酵母生物膜的形成过程包括黏附、增殖、成熟、分散步骤;其结构由多糖、蛋白质及脂质、胞外DNA及周围环境中的一些物质组成;致病因素包括细胞外基质及DNA、生物膜形成及致病相关蛋白、群体感应分子及与其他微生物之间的相互作用。目前的生物膜防治策略主要有研发新型抗菌药、中药单体成分的研究、改良生物医学材料及新型疗法。
Candida albicans is one of the most common pathogens causing hospital-acquired infections.The formation of biofilm is an important pathogenic factor of C.albicans and can greatly enhance its resistance to drugs.The formation process of C.albicans biofilm includes adhesion,proliferation,maturation,and dispersion steps.Its structure is composed of polysaccharides,proteins and lipids,extracellular DNA and some substances in the surrounding environment.Pathogenic factors include extracellular matrix and DNA,biofilm formation,pathogenicity-related proteins,quorum sensing molecules and interactions with other microorganisms.The current biofilm prevention strategies mainly include research and development of new antibacterial drugs,monomer components of traditional Chinese medicine,modified biomedical materials and novel therapies.
作者
黄筱雪
李燕
HUANG Xiao-xue;Li Yan(Chengdu University of TCM,Chengdu,Sichuan 611137,China)
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2019年第21期3350-3354,共5页
Chinese Journal of Nosocomiology
基金
成都中医药大学杏林学者科研基金资助项目(JSZX2018006)
关键词
白假丝酵母
生物膜
形成过程
结构组成
致病因素
防治策略
Candida albicans
Biofilm
Formation process
Structural composition
Pathogenic factor
Prevention strategy
