摘要
目的:探究血清血管生成素样蛋白4(ANGPTL4)、血管生成素样蛋白6(ANGPTL6)水平与妊娠期糖尿病(GDM)胰岛素抵抗的相关性。方法:选择2017年5月-2018年5月在本院产科入住的妊娠期糖尿病58例为GDM组,正常健康孕妇60例为对照组,收集相关信息和标本,分析ANGPTL4、ANGPTL6与HOMA-IR的相关性及影响胰岛素抵抗的危险因素。结果:GDM组的血糖血脂胰岛素指标(TG、VEGF、HbAlc、FPG、FINS、HOMA-IR)水平均高于对照组,HDL-C水平低于对照组,ANGPTL4、ANGPTL6水平均低于对照组(均P<0.05);Pearson相关性分析显示,血清ANGPTL4、ANGPTL6与HOMA-IRI均呈负相关(r=0.653、0.777,P=0.001、0.000);多元线性回归分析显示,ANGPTL4是影响胰岛素抵抗的危险因素。结论:血清ANGPTL4、ANGPTL6在GDM患者中均显著降低,其与葡萄糖耐量,胰岛素抵抗有密切联系。
Objective:To explore the relationship between levels of serum angiopoietin-like protein 4(ANGPTL4)and angiopoietin-like protein 6(ANGPTL6)and insulin resistance of pregnant women with gestational diabetes mellitus(GDM).Methods:58 pregnant women with GDM were selected in study group from May 2017 to May 2018,and 60 healthy pregnant women were in control group.The information of women in the two groups were collected,and the the relationship between serum ANGPTL4 and ANGPTL6 levels and insulin resistance index(HOMA-IR)and the risk factors affecting insulin resistance were analyzed.Results:The levels of triglyceride(TG),VEGF,glycated hemoglobin(HbAlc),fasting blood glucose(FPG),fasting insulin(FINS),and HOMA-IR of women in the study group were significant higher than those of women in the control group,but the levels of ANGPTL4 and ANGPTL6 of women in the study group were significant lower(P<0.05).Pearson correlation analysis showed that serum ANGPTL4 and ANGPTL6 levels were negatively correlated with HOMA-IRI(r=0.653,0.777,P=0.001,0.000).Multiple linear regression analysis showed that ANGPTL4 level was a risk factor of insulin resistance.Conclusion:Serum ANGPTL4 and ANGPTL6 levels of pregnant women with GDM have significantly decreased,which are closely related to their glucose tolerance and insulin resistance.
作者
陈雪蓉
沈冉
靳晴
孟海云
鹿莎
牛兆仪
CHEN Xuerong;SHEN Ran;JIN Qing;MENG Haiyun;LU Sha;NIU Zhaoyi(Yan'an Hospital Affiliated to Kunming Medical University,kunming,Yunnan Province,650000)
出处
《中国计划生育学杂志》
2019年第12期1686-1689,共4页
Chinese Journal of Family Planning
