摘要
目的根据处方中各药的性质,结合本院实际生产条件,优选适宜的工艺制备参数。方法以浸膏得率为评价指标,常规筛选符合实际的适宜制备工艺。结果制剂处方组成中的煅自然铜、血竭、三七、乳香、没药、当归按粉碎工艺粉碎成细粉;另取处方量的红花、骨碎补、续断三味中药的煎煮工艺为:料液比1:12、浸泡3h、煎煮2次、每次2.5h。煎煮液静置沉淀,滤过,滤液常压浓缩至稠膏状,于烘箱70℃干燥成粉末状,与上述细粉混匀,干燥,过筛;另取处方量的冰片研成细粉,与以上细粉混匀,装入空心胶囊,即得胶囊剂。结论该制备方法实际生产可操作性大,稳定可行。
Objective To select the appropriate preparation parameters by combination with the actual production conditions of the hospital according to the nature of drugs in the prescription. Methods The extraction rate of extractum was set as the evaluation index,and suitable preparation technology was conventionally screened in line with actual situation. Results The prescription amount of frankincense,myrrh,dragon blood,radix notoginseng,angelica,calcined natural copper powder were taken and they were pulverize into fine powder.The prescription amount of safflower,drynaria fortunei and radix dipsaci were taken.12 times the amount of water was added to fully soak for 3 h.Then it was decocted for twice and each time lasted for 2.5 h.The decoctions were mixed,placed and filtered.The filtrate was concentrated at normal pressure until it stuck to the rod in sheets without falling.After the extractum was dried,dry extractum powder was obtained,which was mixed with above fine powder.They it was dried and sieved.Another borneol was finely ground and mixed with the above fine powder.Then it was put into a hollow capsule. Conclusion The preparation method is practicable,stable and feasible in practical production.
作者
张艳霞
罗瑜
李学明
ZHANG Yanxia;LUO Yu;LI Xueming(Shaoguan Hospital of Traditional Chinese Medicine,Guangdong,Shaoguan 512026,China)
出处
《中国医药科学》
2019年第21期39-42,158,共5页
China Medicine And Pharmacy
关键词
消瘀痛胶囊
制备工艺
正交试验
胶囊内容物
Stasis-pain elimination capsules
Preparation technology
Orthogonal test
Capsule content
