摘要
背景:聚醚醚酮及其复合材料具有一系列独特的性能,而3D打印技术可以针对患者的病情定制个性化植入物,两者在骨缺损修复领域均具有明显优势。目的:总结聚醚醚酮及其复合材料与3D打印技术在骨缺损修复领域的应用现状,并进一步展望两者有效结合的应用前景。方法:利用计算机检索CNKI、PubMed,Web of Science数据库,中文检索词为“聚醚醚酮,聚醚醚酮复合材料,骨缺损修复,聚醚醚酮植入物,聚醚醚酮3D打印,口腔修复”。英文检索词为“PEEK,PEEK composites,bone defect repair,PEEK implants,PEEK 3D printing,prosthodontics”。检索时限为1995年4月至2019年4月。共检索到147篇文章,根据纳入与排除标准,最终纳入51篇文献进行综述。结果与结论:①将具有生物活性的材料及改善力学性能的颗粒或纤维引入到聚醚醚酮基体中制备成复合材料,借助3D打印技术精准定制出与患者骨缺损处高度匹配的植入物;②这种具有良好生物相容性、生物活性和力学性能的植入物在颅骨、颌骨、脊椎腰椎、人工关节以及口腔缺损修复中具有良好的治疗效果,提高了治疗后患者的满意度;③文章总结了3D打印聚醚醚酮及其复合材料在各类骨缺损修复中的应用,并对联合3D打印技术制备个性化聚醚醚酮植入物或假体的应用前景表达了自己的看法。
BACKGROUND:Polyetheretherketone(PEEK)and its composites have a unique set of properties,and 3D printing technology can customize personalized implants according to the patient's condition,and the effective combination of the two plays a significant role in the field of bone repair.OBJECTIVE:To summarize the application status of PEEK and its composite combined with 3D printing technology in the field of bone repair,and to further predict the application prospects of the effective combination of the two.METHODS:CNKI,PubMed,and Web of Science databases were retrieved with the search terms“PEEK,PEEK composites,bone defect repair,PEEK implants,PEEK 3D printing,prosthodontics”in English and Chinese,respectively,for the articles published from April 1995 to April 2019.Totally 147 articles were searched,and finally 51 eligible articles were enrolled for review in accordance with the inclusion and exclusion criteria.RESULTS AND CONCLUSION:Biologically active materials and the particles or fibers with improved mechanical properties were introduced into the PEEK matrix to prepare its composite.3D printing technology was used to precisely customize implants that are highly matched to the patient's defect.The implants with good biocompatibility,bioactivity,and mechanical properties exhibited good therapeutic effects in the repair of skull,jaw,spine,lumbar vertebra,artificial joint and oral defects.They improved patient satisfaction after treatment.This article summarized the application of PEEK,its composite and 3D printing technology in the repair of various bone defects,and expressed its views on the application and prospect of personalized PEEK implants or prostheses prepared with 3D printing technology.
作者
林柳兰
周建勇
Lin Liulan;Zhou Jianyong(Engineering Technology Training Center,Shanghai University,Shanghai 200444,China)
出处
《中国组织工程研究》
CAS
北大核心
2020年第10期1622-1628,共7页
Chinese Journal of Tissue Engineering Research
关键词
聚醚醚酮
复合材料
骨缺损修复
骨科植入物
假体
3D打印技术
人工关节
口腔修复
PEEK
composite materials
bone defect repair
orthopedic implants
prosthesis
3D printing technology
artificial joint
oral repair
