摘要
目的 分析我院临床常见胆道感染病原菌的分布及耐药性变迁。方法 收集天津市南开医院2016-2018年的胆汁培养病原菌,采用Vitek 2Compact对其进行鉴定及药敏,用whonet 5.6和SPSS 20.0软件对结果进行回顾性分析。结果 胆汁培养共分离病原菌4294株,其中革兰阴性菌2808株,占65.39%;革兰阳性菌1438株,占33.49%;真菌48株,占1.12%。前4位致病菌是大肠埃希菌、肺炎克雷伯菌肺炎亚种、屎肠球菌和粪肠球菌。大肠埃希菌对哌拉西林、哌拉西林/他唑巴坦和左氧氟沙星的耐药率呈上升趋势;肺炎克雷伯菌肺炎亚种对哌拉西林和哌拉西林/他唑巴坦的耐药率亦呈逐年上升趋势。结论 我院胆汁培养病原菌以革兰阴性杆菌为主,菌株耐药性不断变迁,加强抗菌药物管理对临床医生的诊疗至关重要。
Objective To investigate the distribution and changes in antimicrobial resistance of the common pathogens from clinical bile cultures.Methods The bile culture samples in Tianjin NanKai Hospital between 2016 and 2018 were collected,and the identification of bacteria and susceptibility test were performed by Vitek 2 Compact.Results were analyzed based on whonet 5.6 and SPSS 20.0 software.Results A total of 4294 strains of pathogens were isolated from bile.There were 2808(65.39%)strains of Gram-negative bacteria,1438(33.49%)strains of Gram-positive bacteria and 48(1.12%)strains of fungi.The top four bacteria were Escherichia coli,Klebsiella pneumoniae pneumoniae,Enterococcus faecium and Enterococcus faecalis.The resistance rate of Escherichia coli to piperacillin,piperacillin/tazobactam and levofloxacin increased.The resistance rate of Klebsiella pneumoniae pneumoniae to piperacillin and piperacillin/tazobactam also increased year by year.Conclusion The pathogens of bile culture in our hospital are mainly Gram-negative bacilli,and the drug resistance is constantly changing.Therefore,strengthening the management of antibiotics are crucial for the diagnosis and treatment of clinicians.
作者
陈明慧
陈莎燕
房杰
孙兰菊
曾昭伟
常艳敏
CHEN Ming-hui;CHEN Sha-yan;FANG Jie(Department of Laboratory Science,Tianjin NanKai Hospital,Tianjin 300100,China)
出处
《中国实验诊断学》
2019年第12期2081-2085,共5页
Chinese Journal of Laboratory Diagnosis
关键词
胆道感染
病原菌
耐药性
Biliary tract infection
pathogenic bacteria
antimicrobial resistance
