摘要
目的探讨益生菌对非酒精性脂肪肝(non-alcoholic fatty liver disease,NAFLD)患儿肝功能、糖脂代谢及肠道菌群等方面的影响,为进一步分析益生菌治疗NAFLD的可行性和有效性提供参考。方法纳入2017年6月至2018年12月在宁波市奉化区人民医院确诊的120例NAFLD患儿,随机划分为观察组和对照组各60例。对照组接受饮食运动疗法,观察组在对照组基础上给予益生菌口服,持续干预治疗3个月。比较2组患儿干预前后肝功能指标、糖脂代谢指标、粪便菌群失调的差异。结果治疗前,两组患儿丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)、谷氨酰胺转移酶(GGT)、总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、胰岛素抵抗指数(HOMA-IR)及粪便菌群失调率比较,差异均无统计学意义(P值均>0.05)。治疗后,对照组及观察组ALT(30.49±11.03,24.76±9.54)U/L,AST(37.66±12.91,32.05±12.38)U/L、GGT(20.81±8.32,16.07±6.69)U/L,TC(3.90±0.93,3.41±0.87)mmol/L,TG(1.50±0.42,1.14±0.40)mmol/L,HOMA-IR(1.46±0.53,1.22±0.45)比较发现,观察组均高于对照组,差异均有统计学意义(t值分别为3.04,2.43,3.44,2.98,4.81,2.67,P值均<0.05);观察组治疗后粪便菌群失调率优于对照组,差异有统计学意义(Hc=8.34,P=0.02)。结论益生菌有助于改善NAFLD患儿肝功能、糖脂代谢及肠道菌群失调,从而改善NAFLD治疗效果。
Objective To investigate the effects of probiotics on liver function, glucose and lipids metabolism, fecal flora in children with nonalcoholic fatty liver disease(NAFLD), and to further provide a reference for analyzing the feasibility and effectiveness of the treatment of NAFLD. Methods A total of 120 children with NAFLD during June 2017 to December 2018 in The Fenghua People’s Hospital of Ningbo were randomly divided into observation group and control group, 60 cases in each group. The control group received diet and exercise therapy, while the observation group received orally probiotics based on the control group, and the intervention lasted for 3 months. The indexes of liver function, glucose and lipids metabolism, the effective rate and imbalance of fecal flora in two groups were compared before and after intervention. Results Before treatment, there were no significant differences in alanine aminotransferase(ALT), aspartate aminotransferase(AST), glutamine transferase(GGT), total cholesterol(TC), triglyceride(TG), low density lipoprotein cholesterol(LDL-C), high density lipoprotein cholesterol(HDL-C), insulin resistance index(HOMA-IR) and imbalance of fecal flora in two groups were compared before and after intervention(P>0.05). For the comparisons after treatment in two groups, including the ALT(30.49±11.03 vs 24.76±9.54)U/L, AST(37.66±12.91 vs 32.05±12.38)U/L, GGT(20.81±8.32 vs 16.07±6.69)U/L, TC(3.90±0.93 vs 3.41±0.87)mmol/L, TG(1.50±0.42 vs 1.14±0.40)mmol/L, HOMA-IR(1.46±0.53 vs 1.22±0.45), these parameters in observation group was higher than those in control group, and the differences were statistically significant(t=3.04,2.43,3.44,2.98,4.81,2.67,P<0.05);After treatment, the imbalance of fecal flora in the observation group was better than that in the control group, and the difference was statistically significant(Hc=8.34, P=0.02). Conclusion Probiotics are beneficial for liver function, glucose and lipid metabolism, fecal flora for NAFLD patients in children, so as to enhance the therapeutic effect of NAFLD.
作者
汪玲娟
张建萍
陈慕恒
WANG Lingjuan;ZHANG Jianping;CHEN Muheng(Department of Pediatrics,The Fenghua People's Hospital of Ningbo City,Ningbo(315500),Zhejiang Province,China)
出处
《中国学校卫生》
CAS
北大核心
2019年第10期1545-1548,共4页
Chinese Journal of School Health
关键词
细菌
脂肪肝
肝功能试验
脂类代谢
儿童
Bacteria
Fatty liver
Liver function tests
Lipidmetabolism
Child
