摘要
目的:观察中风防治灵1号治疗急性缺血性脑卒中气虚血瘀证恢复期患者的疗效及安全性。方法:180例患者随机分为中药组、西药组和联合组,各60例。在常规治疗基础上,分别口服中风防治灵1号(中药组)、阿司匹林组(西药组)和中风防治灵1号+阿司匹林(联合组),疗程均为2个月。观察临床有效率、临床症状、血液流变学、炎症相关因子、不良反应发生率。结果:研究期间脱落9例。联合组总有效率96.6%(57/59),高于中药组的87.7%(50/57)和西药组的85.5%(47/55);联合组患者NFDS、MMSE和SIS评分较中药组和西药组明显改善;联合组患者血液流变学指标和血清炎性因子较中药组和西药组明显降低;不良反应发生率比较:中药组(1.8%,1/57)<联合组(6.8%,4/59)<西药组(18.2%,10/55);血常规和尿常规异常指标发生率比较:中药组(5.3%,3/57)<联合组(10.2%,6/59)<西药组(27.3%,15/55)。结论:中风防治灵1号治疗缺血性脑卒中气虚血瘀证恢复期安全有效,中风防治灵1号联合阿司匹林具有增效减毒的作用。
Objective:To observe the efficacy and safety of Zhongfeng fangzhiling 1 on cerebral arterial thrombosis in patients with Qixuxueyu syndrome in convalescence.Methods:180 patients were randomly divided into the traditional Chinese medicine group,the western medicine group and the combined group,60 cases each.Besides the routine treatment,Zhongfeng fangzhiling 1,aspirin and Zhongfeng fangzhiling 1+aspirin were orally administered for 2 months.After administration,the clinical effective rate,clinical symptoms,hemorheology,inflammatory related factors and adverse reactions were observed.Results:9 cases dropped out during the treatment.The total effective rate in the combined group was 96.6%(57/59),which was higher than 87.7(50/57)in the traditional Chinese medicine group and 85.5%(47/55)in the western medicine group.Compared to the traditional Chinese medicine group and the western medicine group,the scores of NFDS,MMSE and SIS in the combined group were significantly increased,the hemorheology and serum inflammatory factors in the combined group were significantly decreased.The incidences of adverse reactions were as below:traditional Chinese medicine group(1.8%,1/57)<the combined group(6.8%,4/59)<the western medicine group(18.2%,10/55).The incidences of abnormal indicators of blood routine and urine routine were as below:Chinese medicine group(5.3%,3/57)<the combined group(10.2%,6/59)<the western medicine group(27.3%,15/55).Conclusion:Zhongfeng fangzhiling 1 is safe and effective in the treatment of cerebral arterial thrombosis with Qixuxueyu syndrome.Combined with aspirin,Zhongfeng fangzhiling 1 is more effective and has less adverse reactions.
作者
王改凤
王松龄
Wang Gaifeng;Wang songling(Encephalopathy department,Henan province hospital of TCM,Zhengzhou 450002)
出处
《中药药理与临床》
CAS
CSCD
北大核心
2019年第5期151-154,共4页
Pharmacology and Clinics of Chinese Materia Medica
基金
全国名老中医药专家传承工作室建设项目[国中医药人教函(2018)134号]
关键词
中风防治灵1号
缺血性脑卒中
气虚血瘀证
恢复期
Zhongfeng fangzhiling 1
cerebral arterial thrombosis
Qixuxueyu syndrome
convalescence
