摘要
目的探讨多西环素与氢氧化钙糊剂根管内封药联用于慢性根尖周炎患儿的临床疗效。方法将沈阳医学院附属中心医院口腔科2016年9月至2018年2月收治的100例慢性根尖周炎患儿随机分为对照组与试验组,各50例。对照组于根管内放入甲醛甲酚药捻,试验组采用多西环素、氢氧化钙糊剂根管内封药治疗,比较两组治疗效果、疼痛评分、封药次数及根尖周骨密度增长值。结果试验组治疗后6个月成功率为98.48%,治疗后12个月成功率为95.45%,均高于对照组的85.94%和78.13%,差异有统计学意义(χ2=7.204,P<0.05;χ2=8.585,P<0.05);试验组封药1次率为95.45%,封药2次率为3.03%,与对照组的75.00%、18.75%比较,差异有统计学意义(χ2=10.894,P<0.05;χ2=8.355,P<0.05);治疗后1周试验组视觉模拟评分法(VAS)评分显著低于对照组,差异有统计学意义(t=4.030,P<0.05);试验组治疗后6个月与12个月的根尖周骨密度增长值均显著高于对照组,差异有统计学意义(t=9.873,P<0.05;t=8.247,P<0.05)。结论慢性根尖周炎患儿联合采用多西环素及氢氧化钙糊剂治疗效果确切,既能减少封药次数、加速牙周组织再生,又可缓解疼痛、提高治疗成功率。
Objective To explore the clinical effects of doxycycline and calcium hydroxide paste in the treatment of patients with chronic periapical periodontitis. Methods From September 2016 to February 2018, 100 child patients with chronic periapical periodontitis were randomly divided into control group and experimental group, with 50 cases in each group. In the control group, formaldehyde cresol was added to the root canal. The experimental group was treated with doxycycline and calcium hydroxide paste in the root canal. The treatment effect, pain score, number of sealing and apical pericardial bone density growth value were compared between the 2 groups. Results The success rate of the experimental group was 98.48% after the treatment of 6 months, and the success rate was 95.45% after treatment for 12 months, which was higher than 85.94% and 78.13% of the control group. The difference of treatment success rate between the 2 groups was statistically significant(χ2=7.204, P<0.05;χ2=8.585, P<0.05);the primary rate of sealing in the experimental group was 95.45%, and the second rate of sealing was 3.03%, which was statistically significant compared with 75.00% and 18.75% of the control group(χ2=10.894, P<0.05;χ2=8.355, P<0.05);the VAS score of the experimental group was significantly lower than that of the control group after treatment.(t=4.030, P<0.05);the experimental group was treated for 6 months and 12 months after treatment and the periapical bone density increase was significantly higher than that in the control group(t=9.873, P<0.05;t=8.247, P<0.05). Conclusion The treatment child patients with chronic apical periodontitis combined with doxycycline and calcium hydroxide paste is effective, which can reduce the number of sealing, accelerate the regeneration of periodontal tissue, relieve pain and improve the success rate of treatment.
作者
张妍
赵靓
ZHANG Yan;ZHAO Liang(Department of Stomatology,Affiliated Central Hospital of Shenyang Medical College,Shenyang 110024,China)
出处
《中国药物经济学》
2019年第11期52-55,共4页
China Journal of Pharmaceutical Economics
关键词
根管内封药
多西环素
慢性根尖周炎
氢氧化钙糊剂
小儿
Root canal sealant
Doxycycline
Chronic apical periodontitis
Calcium hydroxide paste
Children
