摘要
整合素连接激酶(ILK)是整合素细胞内外信号转导通路中一个较为重要的效应器,也是多种信号转导通路的枢纽,参与整合蛋白、生长因子介导等信号转导通路的调控,经多条信号转导途径,影响并参与肿瘤细胞的分化、侵袭和转移等。组织中ILK过表达或持续性被激活,可促进致瘤性转化和成瘤性增加,使肿瘤的侵袭力增强。ILK在乳腺癌、前列腺癌、卵巢癌等肿瘤组织中过度表达,并与肿瘤的临床分级、病理分期和预后有关。深入开展ILK在消化道肿瘤中的研究,可能为肿瘤的早期诊断、病理分期、疗效观察和预后判断提供新的途径。
Integrin-linked kinase(ILK)is an important effector in the intracellular and extracellular signal transduction pathwaysof integrin,and also the hub of many signal transduction pathways,which is involved in the regulation of integrin,growth factor-mediated signaling pathways,affecting and being involved in the differentiation,invasion and metastasis of tumor cells through multiple signaling pathways.The hyperexpression or persistent activation of ILK in tissues can promote tumorigenic transformation and increase tumorigenesis,and increase the invasiveness of tumors.ILK is overexpressed in tumor tissues such as breast cancer,prostate cancer,and ovarian cancer,and is associated with clinical grade,pathological stage,and prognosis of tumors.In-depth study of ILK in digestive tract tumors may provide a new way for the early diagnosis,pathological staging,efficacy observation and prognosis judgment of tumors.
作者
侯建章
张金生
侯振江
HOU Jianzhang;ZHANG Jinsheng;HOU Zhenjiang(Department of General Surgery,Cangzhou People′s Hospital Tumor Branch,Cangzhou 061001,China;Institute of Thyroid Diseases Affiliated to Cangzhou Medical College,Cangzhou 061001,China)
出处
《医学综述》
2019年第22期4444-4448,共5页
Medical Recapitulate
关键词
消化道肿瘤
整合素连接激酶
食管鳞状细胞癌
胃癌
肝细胞癌
Gastrointestinal carcinomas
Integrin-linked kinase
Esophageal carcinoma
Gastric cancer
Hepatocellular carcinoma
