摘要
目的探讨激素分别联合他克莫司、来氟米特治疗IgA肾病的临床治疗效果。方法选取辉县市人民医院2015年3月-2018年10月期间66例IgA肾病患者,随机分组,A组采用激素+他克莫司,B组患者给予激素+来氟米特,对比两组患者临床疗效。结果 A组和B组完全缓解率分别为69.70%、45.45%,对比有差显著异(P <0.05);A组治疗后24h尿蛋白(Upr)、血清白蛋白(ALB)、血尿素氮(BUN)、肌酐(Scr)水平均优于B组(P <0.05);A组和B组不良反应发生率对比无显著差异(P> 0.05)。结论激素联合他克莫司治疗IgA肾病,可提高疗效,改善多种指标,且用药安全有效,效果优于激素联合来氟米特,值得临床应用。
Objective To investigate the effect of hormones combined with tacrolimus and leflunomide in the treatment of IgA nephropathy. Methods 66 patients with IgA nephropathy in huixian people’s hospital from March 2015 to October 2018 were randomly assigned to group A with hormone+tacrolimus, and group B with hormone + leflunomide, and the clinical efficacy of the two groups were compared. Results The complete response rates of group A and group B were 69.70% and 45.45%, respectively. The contrast is significant differences(P < 0.05). The levels of urine protein(Upr), serum albumin(ALB), blood urea nitrogen(BUN) and creatinine(Scr) in group A were higher than those in group B at 24 h after treatment(P < 0.05). There was no significant difference in the incidence of adverse reactions between group A and group B(P > 0.05). Conclusion Hormones combined with tacrolimus in the treatment of IgA nephropathy can improve the efficacy and a variety of indicators, which is safe and effective. That effect is better than hormone combination leflunomide, which is worthy of clinical application.
作者
姚辉娟
YAO Huijuan(Department of Nephrology,Huixian People's Hospital,Huixian,Henan,453600,China)
出处
《临床研究》
2020年第1期60-61,共2页
Clinical Research
