摘要
目的探讨不同剂量地塞米松治疗血循毒蛇咬伤的临床效果及安全性。方法选择2017年6月~2018年4月我院收治的血循毒蛇咬伤患者84例作为研究对象,按随机原则分为对照组和观察组各42例,对照组给予常规剂量地塞米松治疗,观察组给予大剂量地塞米松治疗,观察比较两组患者的疼痛消失时间,胸闷、头晕消失时间,皮温恢复正常时间,肿胀消退时间以及平均住院时间、不良反应发生率。结果两组轻度肿胀患者的各项症状改善时间、平均住院时间比较,差异均无统计学意义(均P>0.05);而中度肿胀、重度肿胀患者比较,观察组的各种症状改善时间、平均住院时间均显著短于对照组,差异均有统计学意义(均P<0.05)。观察组的不良反应发生率为11.90%,对照组为7.14%,两组比较差异无统计学意义(P>0.05)。结论使用地塞米松治疗血循毒毒蛇咬伤患者时,可根据患者肢体肿胀程度选择地塞米松的使用剂量,轻度肿胀患者应用常规剂量治疗,中、重度肿胀患者选择大剂量治疗均是安全可行的。
Objective To investigate the clinical effect and safety of different doses of dexamethasone in the treatment of hematotoxin viper snakebites. Methods 84 patients bitten by hematotoxin viper snakebite from June 2017 to April 2018 in our hospital were selected as the study subjects.They were divided into control group(n=42,conventional dose of dexamethasone) and observation group(n=42,large dose of dexamethasone) according to the order of visiting.The pain disappearance time,chest tightness and dizziness disappearance time,skin temperature recovery time and swelling fading time,average hospitalization time and adverse reaction rate were observed and compared between the two groups. Results There were no significant difference in the improvement time of symptoms and average hospitalization time between the two groups(P>0.05 for both).For patients with moderate or severe swelling,the improvement time of symptoms and hospitalization time in the observation group were significantly shorter than those in the control group(P<0.05 for each).Meanwhile,there was no significant difference in the incidence of adverse reactions between the observation group and the control group(11.90% vs 7.14%,P>0.05). Conclusion When using dexamethasone to treat patients bitten by hematotoxin viper snakebite,the dosage of dexamethasone can be selected according to the degree of swelling of the limbs of the patients, the routine dosage can be chosen for patients with mild swelling,and the large dosage can be chosen for patients with moderate and severe swelling,which is safe and feasible.
作者
邓晓东
陆菲菲
DENG Xiao-dong;LU Fei-fei(Wuzhou Hospital of Traditional Chinese Medicine,Wuzhou,Guangxi,543000,China;Wuzhou Hospital of Integrated Traditional Chinese and Western Medicine,Wuzhou,Guangxi,543000,China)
出处
《蛇志》
2019年第4期453-455,共3页
Journal of Snake
关键词
地塞米松
血液毒素
肢体肿胀
Dexamethasone
Hematotoxin
Extremity swelling
