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三维适形调强放疗联合多西他赛对中晚期食管癌的治疗作用研究 被引量:3

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摘要 目的探究三维适形调强放疗联合多西他赛对中晚期食管癌的治疗作用。方法选取安阳市肿瘤医院2016年1月-2018年12月收治的80例中晚期食管癌患者,按随机数字表法将其分为观察组(n=40)和对照组(n=40)。对照组给予三维适形调强放疗,5天/周,总剂量60~66Gy,30~33次,6~6.6周;观察组在此基础上在放疗当天给予多西他赛100mg/m2联合化疗,1个周期为3周,共12周。观察两组近期疗效、外周T淋巴细胞群水平及不良反应发生情况。结果观察组近期有效率为92.50%,明显高于对照组的52.50%(P<0.05)。与治疗前比,观察组治疗后CD4+/CD8+、CD4+、CD3+水平升高,CD8+水平下降(P<0.05);对照组CD4+、CD3+、CD8+水平下降(P<0.05);观察组CD4+/CD8+、CD4+、CD3+水平高于对照组(P<0.05)。两组治疗期间不良反应发生之间无显著差异(P>0.05)。结论中晚期食管癌患者应用三维适形调强放疗联合多西他赛治疗的近期疗效显著,可以改善患者免疫功能,无严重不良反应,安全性较好。
作者 王燕霞
出处 《临床研究》 2019年第12期66-67,共2页 Clinical Research
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