摘要
衰老与机体内肝脏脂质代谢失调有关。尽管衰老与非酒精性脂肪肝(non-alcoholic fatty liver disease,NAFLD)患病率之间没有线性关系,但目前研究表明衰老过程中肝脏脂质代谢因子的变化会影响NAFLD。胰岛素、瘦素和脂联素是调节肝脏脂质代谢的关键调节因子。最新的研究突出了调节因子如成纤维细胞生长因子(Fibroblast growth factor-21,FGF-21)和线粒体衍生肽的作用。在本文中,我们将综述衰老过程中肝脏脂质代谢的调节因子对NAFLD的影响,为防治老年人NAFLD提供了理论基础。
Aging is related to the disorder of lipid metabolism in the liver of the body.Although there is no linear relationship between aging and prevalence of non-alcoholic fatty liver disease(NAFLD),the present studys shows that the changes of the lipidmetabolism in the liver can affect NAFLD.Hepatic lipid accumulation could lead to significant hepatic and systemic consequences including steatohepatitis,cirrhosis,impairment of systemic glucose metabolism and metabolic syndrome,thereby contributing to aging-related diseases.Insulin,leptin and adiponectin are key regulators of the various physiologic processes that regulate hepatic lipid metabolism.Recent advances have expanded our understanding in this field,highlighting the role of mediators such as fibroblast growth factor-21(FGF-21),and mitochondria derived peptides.In this review,we will summarize the effects of liver lipid metabolism regulators on NAFLD during aging,which provides a theoretical basis for the prevention and treatment of NAFLD in the elderly.
作者
吴雨龙
华春
WU Yu-long;HUA Chun(School of Food Science,Nanjing Xiaozhuang University,Nanjing 211171,China;Jiangsu Provincial Key Construction Laboratory of Special Biomass Waste Resource Utilization,Nanjing 211171,China)
出处
《南京晓庄学院学报》
2019年第6期1-4,13,共5页
Journal of Nanjing Xiaozhuang University
基金
江苏省自然科学基金(BK20141081)
江苏省高校重点建设实验室项目(苏教科[2016]8)
南京市环境科学与工程重点建设学科项目
南京晓庄学院青年专项(2016NXY45)
关键词
衰老
非酒精性脂肪肝
肝脏脂质代谢
aging
non-alcoholic fatty liver disease
hepatic lipid metabolism
