摘要
目的:探讨产妇安合剂联合米非司酮治疗气虚血瘀型产后恶露不绝的临床疗效及对子宫三径的影响。方法:对2017年12月至2019年3月湖北省第三人民医院收治的98例气虚血瘀型产后恶露不绝患者的临床资料进行回顾性分析,根据治疗方式的不同分为观察组、对照组,每组49例。对照组患者采用米非司酮治疗,观察组患者在对照组基础上联合产妇安合剂治疗,比较两组患者的临床疗效、不良反应和输血发生情况、中医症候积分以及子宫三径水平变化。结果:观察组患者的治疗总有效率为89.80%(44/49),明显高于对照组的71.43%(35/49),差异有统计学意义(P<0.05)。治疗后,两组患者各中医症候积分均较治疗前明显降低,且观察组患者明显低于对照组,上述差异均有统计学意义(P<0.05);两组患儿子宫三径水平均较治疗前明显降低,且观察组明显低于对照组,上述差异均有统计学意义(P<0.05)。两组患者总不良反应发生率的差异无统计学意义(P>0.05);观察组患者输血率明显低于对照组,差异有统计学意义(P<0.05)。结论:产妇安合剂联合米非司酮治疗气虚血瘀型产后恶露不绝的临床疗效显著,可有效改善患者的临床症状,促进子宫复旧,且安全、可靠。
OBJECTIVE: To probe into the clinical efficacy of Chanfuan mixture combined with mifepristone in the treatment of postpartum lochia with Qi deficiency and blood stasis type and its effects on uterine three-diameter. METHODS: Totally 98 patients with Qi deficiency and blood stasis type admitted into the Third People’s Hospital of Hubei from Dec. 2017 to Mar. 2019 were extracted to be divided into the observation group and the control group via different treatment methods, with 49 cases in each group. Patients in the control group was treated with mifepristone, while the observation group received Chanfuan mixture on the basis of the control group. Clinical efficacy, adverse drug reactions and blood transfusion, traditional Chinese medicine(TCM) syndrome scores and uterine three-diameter of two groups were compared. RESULTS: The total effective rate of the observation group was 89.80%(44/49), significantly higher than that of the control group 71.43%(35/49), the difference was statistically significant(P<0.05). After treatment, the TCM syndrome scores of patients in both groups were significantly lower than those before treatment, and the observation group was significantly lower than the control group, with statistically significant differences(P<0.05). The level of uterine three-diameter was significantly lower in both groups compared with before treatment, and the observation group was significantly lower than the control group, with statistically significant differences(P<0.05). There was no statistically significant difference in the total incidence of adverse drug reactions between two groups(P>0.05). The blood transfusion rate of the observation group was significantly lower than that of the control group, and the difference was statistically significant(P<0.05). CONCLUSIONS: The clinical efficacy of Chanfuan mixture combined with mifepristone in the treatment of postpartum lochia with Qi deficiency and blood stasis type is significant, which can effectively improve the clinical symptoms, promote the uterine involution, with higher safety.
作者
李莉
付文岚
严玲玲
LI Li;FU Wenlan;YAN Lingling(Dept.of Obstetrics and Gynecology,the Third People’s Hospital of Hubei,Hubei Wuhan 430000,China)
出处
《中国医院用药评价与分析》
2019年第11期1309-1311,1316,共4页
Evaluation and Analysis of Drug-use in Hospitals of China
基金
湖北省卫生和计划生育委员会科研项目(No.WJ2017M148)
关键词
产妇安合剂
米非司酮
气虚血瘀型产后恶露不绝
临床疗效
Chanfuan mixture
Mifepristone
Postpartum lochia with Qi deficiency and blood stasis type
Clinical efficacy
