摘要
目的观察孟鲁司特钠辅助治疗对慢性阻塞性肺气肿患者肺功能及炎性因子的影响。方法选取2017年12月至2019年6月在甘肃省金昌市金川区公司职工医院接受治疗的慢性阻塞性肺气肿患者92例作为研究对象,采用随机平行分组法将患者分为对照组和观察组,各46例。对照组接受常规治疗,观察组在对照组的基础上接受孟鲁司特钠辅助治疗,观察两组患者的肺功能指标[第一秒用力呼气容积(FEV1)、用力肺活量(FVC)、肺活量(VC)及最大通气量(MMV)]及炎性因子[白细胞介素6(IL-6)、白细胞介素8(IL-8)及肿瘤坏死因子α(TNF-α)]水平。结果观察组患者FEV1、FVC、VC及MMV水平均明显高于对照组,IL-6、IL-8及TNF-α水平均明显低于对照组,差异均有统计学意义(P<0.05)。结论慢性阻塞性肺气肿患者接受孟鲁司特钠辅助治疗,能够有效降低炎性因子水平,提高肺部功能,值得被推广、应用。
Objective To analyze the effect of montelukast sodium on pulmonary function and inflammatory factors in patients with chronic obstructive emphysema.Methods A total of 92 patients with chronic obstructive pulmonary emphysema treated in our hospital from December 2017 to June 2019 were selected as the research subjects.The patients were divided into control group(n=46)and observation group(n=46)by a random parallel grouping method.The control group received routine treatment,and the observation group received montelukast sodium adjuvant treatment on the basis of the control group.The lung function indexes(FEV1,FVC,VC and MMV)and inflammatory factor(IL-6,IL-8 and TNF-α)levels of patients in the two groups were observed.Results The levels of FEV1,FVC,VC and MMV in the observation group were significantly higher than those in the control group,the levels of IL-6,IL-8 and TNF-αwere significantly lower than those in the control group(all P<0.05).Conclusion Montelukast sodium adjuvant therapy for patients with chronic obstructive pulmonary emphysema can effectively reduce the level of inflammatory factors and improve lung function,which is worthy of promotion and application.
作者
刘琼
LIU Qiong(Staff Hospital of Jinchuan Group Co.,LTD.,Jinchang,Gansu 737100)
出处
《大医生》
2019年第15期127-128,共2页
Doctor
关键词
慢性阻塞性肺气肿
孟鲁司特钠
肺功能
炎性因子
chronic obstructive emphysema
montelukast sodium
pulmonary function
inflammatory factor
