摘要
目的研究清热祛湿健脾方对慢性乙型肝炎的治疗效果及对患者免疫细胞水平变化的影响。方法 90例在医院就诊且符合入选标准的患者分为对照组与观察组各45例,均给予恩替卡韦抗病毒治疗,观察组另给予清热祛湿健脾方,治疗周期6个月。治疗结束后,对比两组患者临床疗效、肝功能指标、病原学指标、免疫细胞水平及不良反应发生情况。结果观察组患者的临床总有效率(86.7%)高于对照组(64.4%),差异有统计学意义(χ2=8.630,P=0.003)。两组患者肝功能指标ALT、AST、TBIL较治疗前均降低,且观察组下降幅度高于对照组,差异均有统计学意义(P<0.05)。观察组治疗3个月的HBeAg与HBV-DNA转阴率与对照组差异无统计学意义(P>0.05),治疗6个月的HBeAg与HBV-DNA转阴率均高于对照组,差异有统计学意义(P<0.05)。治疗后,两组患者CD3、CD4、CD8免疫细胞水平、CD4/CD8比值及血清细胞因子IFN-γ、TNF-α、IL-4、IL-6水平较治疗前均有改善,且观察组优于对照组(P<0.05)。两组患者治疗过程中均未发生不良反应。结论清热祛湿健脾方可提高慢性乙型肝炎的临床治疗效果,调节机体的免疫功能。
Objective To evaluate the therapeutic efficacy of Qingre Qushi Jianpi Decoction as a medicine in treating chronic hepatitis B and regulating the level of immune cells in patients with the disease of chronic hepatitis B. Methods Firstly, 90 patients meeting the criteria for admission were chosen as the subjects of study and divided into a control group(n=45) and an experimental group(n=45). Secondly, both groups were then subjected to antiviral treatment with Entecavir for six months where the experimental group were treated with Qingre Qushi Jianpi Formula in addition. Lastly, the clinical efficacy, liver function, etiology, immune cell level and adverse reactions of the two groups as observed after treatment were compared. Results The total clinical effective rate of the experimental group(86.7%) was higher than that of the control group(64.4%). The difference was statistically significant(χ2= 8.630, P=0.003). The the levels of liver function of the two groups in terms of ALT, AST and TBIL were lower than those before treatment, with the decrease thereof in the experimental group being greater than that in the control. The differences were statistically significant(P<0.05). No significant difference in the negative rate of HBeAg and HBV-DNA as observed 3 months after treatment was found between the two groups(P>0.05). Interestingly, the negative rate of HBeAg and HBV-DNA of the experimental group as observed 6 months after treatment was higher than that of the control. The difference was statistically significant(P<0.05). After treatment, the levels of CD3, CD4, CD8 immune cells, the CD4/CD8 ratio and the serum cytokines IFN-γ, TNF-α, IL-4 and IL-6 in the two groups were improved as compared with those before treatment, with the improvement in these aspects in the experimental group being greater than that in the control(P<0.05). No cases of adverse reactions during the course of treatment was found in either group. Conclusions Qingre Qushi Jianpi Decoction as a medicine for treating chronic hepatitis B can significantly improve the clinical efficacy and better the immune function of the body.
作者
章璐璐
郑群飞
朱晶晶
ZHANG Lulu;ZHENG Qunfei;ZHU Jingjing(Department of TCM Pharmacy,Wenzhou Hospital of TCM Affiliated to Zhejiang Chinese Medical University,Wenzhou 325000,China)
出处
《健康研究》
CAS
2019年第6期691-694,共4页
Health Research
关键词
慢性乙型肝炎
清热祛湿健脾方
疗效
免疫细胞
chronic hepatitis B
Qingre Qushi Jianpi formula
curative effect
immune cells
