摘要
目的通过对陕西地区女性人乳头瘤病毒(HPV)感染情况及基因分型研究,为本地区宫颈癌的筛查、预防、治疗以及对宫颈癌疫苗的研制、选择提供依据。方法采用PCR-反向点杂交法对2016年1月至2019年4月期间,对来自于陕西地区的9749例疑似HPV感染病例样本进行HPV基因分型检测。结果9749例疑似病例样本中阳性病例3048例,总体感染率为31.26%;主要的感染类型为单一感染,感染率为19.13%,以高危型感染为主,感染率为14.59%;HPV双重感染次之,为7.12%。3048例HPV阳性样本中高危型占比最高的依次为16型、52型、53型、58型,感染率分别为6.30%、6.09%、3.82%、3.77%,低危型主要集中在6型、81型、43型、42型,感染率分别为3.34%、2.71%、2.39%、2.33%。对所有感染者进行6个年龄组的划分,不同年龄组之间HPV感染率比较差异均具有显著统计学意义(P<0.01),其中HPV感染率最高的是≤20岁年龄组,感染率为52.39%,其次是≥61岁年龄组,感染率为38.46%。21~30岁和31~40岁年龄组的受检人数最多,感染率分别是33.90%、26.60%。结论陕西地区HPV总体感染率较高,以单一感染为主,最为常见的是HPV16、52亚型;≤20岁和≥61岁是HPV的高发人群,应引起重视。
Objective To study the human papillomavirus(HPV)infection rate and genotype distribution among women in Shaanxi,and to provide basic data for screening,prevention and treatment of cervical cancer as well as development and selection of cervical cancer vaccine.Methods Between January 2016 and April 2019,a total of 9749 suspected cases from Shaanxi were collected and the HPV genotypes were tested by PCR reverse spot molecular hybridization.Results Among the 9749 samples,3048 cases were found HPV positive with the overall infection of 31.26%.The single infection was the mainly affection HPV type and the ratio was 19.13%.Most importantly,single HVP infection was the high-risk HPV and the ration was up to 14.59%as compared to the 7.12%of double HPV infection.In the 3048 positive cases,the top four high-risk genotypes were HPV16(6.30%),HPV52(6.09%),HPV53(3.82%)and HPV58(3.77%),and the top four low-risk genotypes were HPV6(3.34%),HPV81(2.71%),HPV43(2.39%),HPV42(2.33%).Furthermore,all of the patients were divided into six groups according to ages and the infection rate of HPV,there were significant differences in the infection rate among different groups(P<0.01).The infection rate was the highest in≤20 years group(52.39%),followed by≥61 years group(38.46%)The most people inspected were 21-30 years old and 31-40 years old,and the infection rates were 33.90%and 26.60%,respectively.Conclusion Human papillomavirus(HPV)infection rate in Shaanxi is higher,and most of them are single infection.The common infection subtypes are HPV16 and HPV52.More attention should be focused on high-risk population who are≤20 years old and≥61 years old.
作者
王蕾
何小波
周再铜
赵芳平
王敏
刘杨
刘孟黎
WANG Lei;HE Xiao-bo;ZHOU Zai-tong;ZHAO Fang-ping;WANG Min;LIU Yang;LIU Meng-li(Xi'an Tianbo Diagnostics Laboratory,Xi’an 710000,Shaanxi,CHINA)
出处
《海南医学》
CAS
2019年第24期3200-3203,共4页
Hainan Medical Journal
关键词
陕西
人乳头瘤病毒
基因亚型
感染
宫颈癌
Xi'an
Human papillomavirus(HPV)
Genotyping
Infection
Cervical cancer
