摘要
目的探究五虫通络胶囊治疗急性脑梗死动脉取栓的治疗效果及预后情况。方法选取我院2015年4月—2017年4月收治的急性脑梗死接受动脉取栓治疗病人86例,采取随机数字表法分为对照组与观察组,每组43例。对照组给予低分子肝素治疗;观察组在对照组基础上加用五虫通络胶囊治疗。对比两组治疗前后神经功能评分、血脂指标及随访3个月期间的继发性脑出血率及血管再闭塞率。结果两组治疗后3 d、7 d及14 d与治疗前相比美国国立卫生研究院卒中量表(NHISS)评分降低,观察组治疗后3 d、7 d及14 d与对照组相比NHISS降低更加显著,差异具有统计学意义(P<0.05)。两组治疗前后比较,三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)降低,高密度脂蛋白胆固醇(HDL-C)升高,且观察组治疗后上述指标改善更加显著,差异均具有统计学意义(P<0.05)。随访3个月观察组与对照组相比继发性脑出血率及血管再闭塞率较低,差异具有统计学意义(P<0.05)。结论急性脑梗死动脉取栓治疗后在实施低分子肝素治疗的基础上加用五虫通络胶囊,能够促进改善病人的神经功能、调节血脂指标,同时也能够降低继发性脑出血率及血管再闭塞率。
Objective To investigate the effect and prognosis of Wuchong Tongluo capsule(WTC)in the treatment of acute cerebral infarction(ACI)with arterial thrombectomy.Methods Eighty-six patients with ACI undergoing thrombectomy were randomly divided into two groups:control group(n=43)treated with aspirin and clopidogrel antiplatelet therapy,and observation group(n=43)treated with WTC in the basis of aspirin and clopidogrel antiplatelet therapy.The neurological score,blood lipid index,secondary cerebral hemorrhage rate,and vascular reocclusion rate during a 3-month follow-up were compared between two groups before and after treatment.Results Compared with before treatment,the National Institutes of Health Stroke Scale(NHISS)scores were lower at 3,7,and 14 days after treatment in two groups,which were lower in the observation group at 3,7,and 14 days after treatment than in the control group(P<0.05).Compared with before treatment,the levels of triacylglycerol,total cholesterol,and low-density lipoprotein cholesterol decreased while high-density lipoprotein cholesterol level increased in the two groups after treatment.The improvement of the indicators was more significant,and the difference was statistically significant(P<0.05).The rate of secondary cerebral hemorrhage and vascular reocclusion in the observation group after 3 months follow-up was lower than those in the control group,and the differences were statistically significant(P<0.05).Conclusion WTC and low molecular heparin therapy can improve the patient′s neurological function and regulate blood lipids,and can also reduce the rate of secondary cerebral hemorrhage and blood vessels reocclusion in patients with ACI after arterial thrombectomy.
作者
牟磊
李茂绪
徐东成
张孟
秦文玲
陈哲
李珊珊
成玉
高志远
张宪忠
MOU Lei;LI Maoxu;XU Dongcheng;ZHANG Meng;QIN Wenling;CHEN Zhe;LI Shanshan;CHENG Yu;GAO Zhiyuan;ZHANG Xianzhong(Rizhao Hospital of Traditional Chinese Medicine Affiliated to Jining Medical University,Rizhao 276800,Shandong,China)
出处
《中西医结合心脑血管病杂志》
2019年第23期3684-3686,共3页
Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease
基金
山东省中医药科技发展计划项目(No.2017-442)
济宁医学院教师科研扶持基金项目(No.JYFC2018FKJ148)
关键词
急性脑梗死
五虫通络胶囊
动脉取栓
继发性脑出血
血管再闭塞
神经功能
血脂
acute cerebral infarction
Wuchong Tongluo capsule
arterial thrombectomy
secondary cerebral hemorrhage
vascular reocclusion
neurological function
blood lipid
