摘要
目的:探讨阿托伐他汀联合苯磺酸左旋氨氯地平对高血压患者平均动脉压及血压变异性的影响。方法:2017年1月-2018年9月收治高血压Ⅱ级患者100例,分为联合服药组和服单药组。联合服药组口服苯磺酸左旋氨氯地平片及阿托伐他汀。服单药组仅服用苯磺酸左旋氨氯地平片。所有患者于服药前、服药12周后24 h行动态血压检查,比较两组平均动脉压及平均血压水平。结果:两组患者在药物干预12周后平均动脉压及平均血压水平比较,差异无统计学意义(P>0.05)。联合服药组药物干预12周后血压变异系数较服单药组显著下降,差异有统计学意义(P<0.05)。结论:阿托伐他汀与苯磺酸左旋氨氯地平联合降压,无提升苯磺酸左旋氨氯地平降低平均动脉压的作用,但有提升苯磺酸左旋氨氯地平降低血压变异系数的作用。
Objective:To investigate the effect of atorvastatin combined with levamlodipine besylate on mean arterial blood pressure and blood pressure variability in patients with hypertension.Methods:100 patients with gradeⅡhypertension were treated from January 2017 to September 2018.They were divided into combination drug group and single drug group.The combination drug group was given levamlodipine besylate and atorvastatin.The single drug group was only given the levamlodipine besylate tablets.All patients received ambulatory blood pressure at 24 h before taking the drug and after taking the drug for 12 weeks.We compared the mean arterial blood pressure and mean blood pressure levels in both groups.Results:The mean arterial blood pressure and mean blood pressure levels were compared after 12 weeks of drug intervention,andthe difference was not statistically significant(P>0.05).After 12 weeks of drug intervention,the coefficient of variation of blood pressure in the combination drug group was significantly lower than the single drug group,andthe difference was statistically significant(P<0.05).Conclusion:The combination of atorvastatin and levamlodipine besylate has no effect on reducing mean arterial blood pressure,but it has the effect of promoting levamlodipine besylate to reduce the coefficient of variation of blood pressure.
作者
王磊
Wang Lei(Jilin Integrated Traditional Chinese and Western Medicine Hospital,Jilin Province 132000)
出处
《中国社区医师》
2019年第36期17-18,共2页
Chinese Community Doctors
关键词
阿托伐他汀
苯磺酸左旋氨氯地平片
高血压
平均动脉压
血压变异性
Atorvastatin
Levamlodipinebesylate
Hypertension
Mean arterial blood pressure
Blood pressure variability
