摘要
目的探讨缺血性脑卒中病人血清淀粉样蛋白A(SAA)表达水平,以及SAA与抑郁发生的关系。方法选择2016年6月至2017年12月启东市人民医院收治缺血性脑卒中62例(研究组)、健康体检者30例(对照组),根据是否并发抑郁症将研究组分为脑卒中后抑郁(PSD)组(15例)和非PSD组(47例)。比较不同组之间人口社会学、生活方式及生物学资料、影像学检查结果及SAA、同型半胱氨酸(Hcy)水平变化,采用多因素logistic回归分析缺血性脑卒中病人血清SAA水平与抑郁的相关性。结果非PSD组、PSD组血清SAA水平明显高于对照组[(167.55±23.18)比(387.23±30.36)比(104.20±14.27)μg/L(P<0.05)];PSD组血清SAA水平、汉密尔顿抑郁量表(HAMD⁃17)评分均较非PSD组明显升高(P<0.05)。抑郁与非抑郁病人在性别、文化程度、高同型半胱氨酸血症(HHcy)、美国国立卫生研究院卒中量表(NIHSS)评分方面比较,均差异有统计学意义(P<0.05)。性别(OR=1.97,95%CI:1.29~2.98)、血清SAA水平(OR=3.25,95%CI:1.88~4.61)及NIHSS评分(OR=1.71,95%CI:1.14~2.54)是缺血性脑卒中病人并发PSD的独立危险因素,而文化程度(OR=0.23,95%CI:0.08~0.61)则是保护性因素(P<0.05)。结论SAA在缺血性脑卒中病人中明显升高,且与PSD的发生密切相关,可作为预测PSD发生的一种生物学标志物。
Objective To explore the expression of serum amyloid A(SAA)and its correlation with depression in patients with ischemic stroke.Methods 62 patients with ischemic stroke(study group)and 30 healthy subjects(control group)admitted to Qi⁃dong People’s Hospital between June 2016 and December 2017 were selected.And study group was divided into PSD group(15 cases)and non⁃PSD group(47 cases)according to whether depression was complicated.Demographic sociology,lifestyle and biolog⁃ical data,imaging examination results and changes in SAA and homocysteine(Hcy)levels between different groups were compared.Multivariate logistic regression was used to analyze the correlation between SAA and the incidence of depression.Results Com⁃pared with control group,the level of serum SAA was significantly increased in non⁃PSD group and PSD group[(167.55±23.18,387.23±30.36 vs.104.20±14.27)μg/L],and the difference was statistically significant(P<0.05).Compared with the non⁃PSD group,the level of serum SAA and HAMD score in PSD group were significantly increased(P<0.05).There were statistically sig⁃nificant differences in gender,educational level,HHcy and NIHSS score between depressed and non⁃depressed patients(P<0.05).Gender(OR=1.97,95%CI:1.29⁃2.98),serum SAA(OR=3.25,95%CI:1.88⁃4.61)and NIHSS score(OR=1.71,95%CI:1.14⁃2.54)were independent risk factors for PSD in patients with ischemic stroke,while education level(OR=0.23,95%CI:0.08~0.61)was a protective factor(P<0.05).Conclusion SAA is significantly increased in patients with ischemic stroke,and closely related to the occurrence of PSD,which can be used as a biological marker to predict the occurrence of PSD.
作者
钱维娜
王莉莉
沈斌
QIAN Weina;WANG Lili;SHEN Bin(Department of Neurology,Qidong People’s Hospital of Jiangsu Province,Qidong,Jiangsu 226200,China)
出处
《安徽医药》
CAS
2020年第1期24-27,共4页
Anhui Medical and Pharmaceutical Journal
