摘要
肿瘤发病机制复杂,自噬在肿瘤进展过程中发挥着双向调节的作用。相关肿瘤体内外研究已经证明,增强癌细胞自噬水平可以促进癌细胞坏死和凋亡。中医药能够显著增强抗肿瘤药物疗效,改善其耐药性,减轻其不良反应,已然成为肿瘤研究的热点。中医药抗肿瘤机制与细胞凋亡、坏死及自噬等多种效应相关。目前,针对细胞自噬的中医药干预肿瘤研究已逐步开展,证实中医药类单体和复方能够提高肿瘤细胞自噬水平,促进细胞凋亡,发挥抗肿瘤作用。但目前的研究尚处于细胞、动物等基础阶段,还需从基因及代谢水平深入探讨其作用机制;同时,如何利用自噬在肿瘤进展过程中的双重效应设计实验及指导临床用药将是研究重点;目前的研究缺乏中药复方的实验设计;此外,在中医药诱导肿瘤细胞自噬性死亡的同时,如何把握其对正常细胞的效应,如何充分利用中医药整体观念指导肿瘤防治仍需深入探索。总之,随着中医药对肿瘤调控机制研究的深入,从细胞自噬角度探索中医药治疗肿瘤的新靶点,将具有重大的临床意义和广泛的应用前景。
The pathogenesis of tumors is complex,and autophagy plays a two-way regulation role in tumor progression. Related in vitro and in vivo studies have demonstrated that enhancing autophagy levels in cancer cells can promote cancer cell necrosis and apoptosis. Traditional Chinese medicine can significantly enhance the efficacy of anti-tumor drugs,improve its drug resistance,and reduce its toxic and side effects,which has become a hot spot in cancer research. The anti-tumor mechanism of traditional Chinese medicine is related to various effects such as apoptosis,necrosis and autophagy. At present,traditional Chinese medicine interventional tumor research on autophagy has been gradually carried out,confirming that Chinese medicine monomers and compounds can increase the level of autophagy in tumor cells,promote apoptosis,and exert anti-tumor effects. However,the current research is still in the basic stage of cells and animals. It is necessary to further explore its mechanism of action from the level of genes and metabolism. At the same time,how to use the dual effect design of autophagy in the process of tumor progression and guide clinical drug use will be the research focus. The current research lacks the experimental design of traditional Chinese medicine compound;in addition,while Chinese medicine induces autophagic death of tumor cells,how to grasp its effect on normal cells,how to make full use of the overall concept of traditional Chinese medicine to guide tumor prevention still needs to be further explored. In short,with the in-depth study of the mechanism of tumor regulation by Chinese medicine,exploring new targets for the treatment of tumors from the perspective of autophagy will have significant clinical significance and broad application prospects.
作者
范修琦
陈玉龙
吴耀松
任闪闪
孟丹华
高启龙
FAN Xiuqi;CHEN Yulong;WU Yaosong;REN Shanshan;MENG Danhua;GAO Qilong(Henan University of Chinese Medicine,Zhengzhou Henan China 450046;The Tumor Hospital Affiliated to Zhengzhou University,Zhengzhou Henan China 450008)
出处
《中医学报》
CAS
2019年第12期2542-2548,共7页
Acta Chinese Medicine
基金
国家自然科学基金项目(81373535)
关键词
自噬
信号通路
肿瘤
中医药
autophagy
signaling pathway
tumor
traditional Chinese medicine
