摘要
目的探讨右佐匹克隆治疗失眠症的临床效果。方法选取2017年10月~2019年4月在我院门诊治疗的80例失眠症患者作为研究对象,根据随机数字表法分为对照组与观察组,每组各40例。对照组患者采用艾司唑仑片治疗,观察组患者使用右佐匹克隆治疗,比较两组患者的临床疗效、匹兹堡睡眠质量指数(PSQI)变化、睡眠状况问卷自评量表(SRSS)评分及不良反应发生情况。结果观察组患者的治疗总有效率为87.50%,与对照组的82.05%比较,差异无统计学意义(P>0.05);观察组患者治疗后的入睡时间、睡眠时间、睡眠障碍、睡眠质量、睡眠效率、睡眠药物、日间功能评分以及PSQI总分均低于对照组,差异有统计学意义(P<0.05);观察组患者治疗后2、4周的SRSS评分低于对照组,差异有统计学意义(P<0.05);观察组患者的不良反应总发生率低于对照组,差异有统计学意义(P<0.05)。结论右佐匹克隆治疗失眠症的临床效果显著,能够有效提升患者的睡眠质量,且不良反应发生率较低,具有积极的临床意义。
Objective To investigate the clinical effect of Eszopiclone in the treatment of insomnia.Methods A total of 80 insomniacs treated in the outpatient department of our hospital from October 2017 to April 2019 were selected as the subjects,and divided into the control group and observation group by random number table method,with 40 cases in each group.The control group was treated with Astazolam Tablets,and the observation group was treated with Eszopiclone.The clinical efficacy,Pittsburgh sleep quality index(PSQI)changes,sleep status questionnaire(SRSS)scores and incidence of adverse reactions of the two groups were compared.Results The total effective rate of the observation group was 87.50%,compared with 82.05% of the control group,the difference was not statistically significant(P>0.05).The scores of sleep time,sleep time,sleep disorder,sleep quality,sleep efficiency,sleep drugs,daytime function and total scores of PSQI in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).The SRSS scores of the observation group at 2 and 4 weeks after treatment were lower than those of the control group,and the differences were statistically significant(P<0.05).The total incidence of adverse reactions in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Eszopiclone is effective in the treatment of insomnia,and can effectively improve the quality of sleep,and the incidence of adverse reactions is lower,which has positive clinical significance.
作者
欧海燕
叶秀儿
甘晓文
何婉婷
OU Hai-yan;YE Xiu-er;GAN Xiao-wen;HE Wan-ting(Department of Psychiatry,Dongguan Seventh People's Hospital,Guangdong Province,Dongguan 523230,China)
出处
《中国当代医药》
2020年第1期60-62,66,共4页
China Modern Medicine
基金
广东省东莞市社会科技发展（一般）项目(2018507150061415)
关键词
失眠症
右佐匹克隆
临床疗效
睡眠质量
Insomnia
Eszopiclone
Clinical curative effect
Sleep quality
