摘要
目的探讨前列地尔注射液治疗急性脑梗死的临床效果。方法选取2018年1月~2019年1月我院收治的100例急性脑梗死患者作为研究对象,按照随机数字表法分为观察组和对照组,每组各50例。对照组采用基础治疗,观察组在对照组的基础上给予前列地尔注射液治疗。比较两组治疗前后的美国国立卫生研究院卒中量表(NIHSS)评分、脑卒中前改良Rankin量表(mRS)评分以及实验室指标;比较两组的不良反应总发生率。结果观察组治疗后第15、30、90天的NIHSS、mRS评分均低于对照组,差异有统计学意义(P<0.05)。观察组治疗后第15天的血小板聚集率、血浆Ⅷ因子相关抗原和组织型纤溶酶原激活物抑制物水平低于对照组,组织型纤溶酶原激活物水平高于对照组,差异均有统计学意义(P<0.05)。两组的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论前列地尔注射液能有效改善急性脑梗死患者的脑神经功能及实验室各指标,且不增加不良反应的发生,值得临床推广应用。
Objective To explore the clinical effect of Alprostadil Injection in the treatment of acute cerebral infarction.Methods A total of 100 patients with acute cerebral infarction admitted to our hospital from January 2018 to January 2019 were selected as the study objects,they were divided into the observation group and the control group according to random number table method,with 50 cases in each group.The control group treated with basic method,and the observation group treated with Alprostadil Injection on the basis of the control group.USA national institutes of health stroke scale(NIHSS)score,modified Rankin scale before stroke(mRS)score and laboratory indexes were compared before and after treatment between the two groups.The total incidence of adverse reactions were compared between the two groups.Results The NIHSS and mRS scores of the observation group were lower than those of the control group on the 15^th,30^th and 90^th days after treatment,the differences were statistically significant(P<0.05).The platelet aggregation rate,plasma factor Ⅷ related antigen and tissue plasminogen activator inhibitor level in the observation group were lower than those in the control group on the 15^th day after treatment,and the tissue plasminogen activator level was higher than that in the control group,the differences were statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Alprostadil Injection can effectively improve the brain nerve function and laboratory indexes of patients with acute cerebral infarction,and does not increase the incidence of adverse reactions,which is worth clinical application.
作者
梁献升
许一帆
李宗洪
LIANG Xian-sheng;XU Yi-fan;LI Zong-hong(The First Department of Internal Medicine-Neurology,Yangjiang People's Hospital of Guangdong Province,Yangjiang 529500,China)
出处
《中国当代医药》
2020年第1期63-66,共4页
China Modern Medicine
基金
广东省阳江市卫生计生局科技计划项目(阳卫计2018012)
关键词
急性脑梗死
前列地尔
神经功能缺损
临床效果
Acute cerebral infarction
Alprostadil
Neurological impairment
Clinical effect
