摘要
目的探讨兰索拉唑联合金胃泰治疗老年慢性浅表性胃炎的安全性和临床疗效,为该病的临床用药提供指导。方法选取2015年6月—2016年6月在该院进行治疗的70例老年慢性浅表性胃炎患者,随机分成对照组(35例)和研究组(35例)。对照组患者予以口服兰索拉唑进行治疗,15 mg/次,1次/d,研究组在对照组的基础上口服金胃泰胶囊,0.9 g/次,3次/d,两组患者疗程均为4周。观察两组患者临床疗效,比较发生不良反应的情况以及治疗6个月的复发情况。结果经治疗,研究组总有效率(91.43%)明显高于对照组(71.43%),差异有统计学意义(χ^2=4.629,P<0.05);研究组不良反应发生率(5.71%)明显低于对照组(22.86%),差异有统计学意义(χ^2=4.200,P<0.05);研究组治疗6个月复发率(3.13%)明显低于对照组(20.00%),差异有统计学意义(χ^2=4.244,P<0.05)。结论兰索拉唑联合金胃泰治疗老年慢性浅表性胃炎有助于提高临床疗效,控制该病的复发率,降低不良反应的发生率,用药安全性更高,临床推广价值显著。
Objective To investigate the safety and clinical efficacy of lansoprazole combined with Jinweitai in the treatment of chronic superficial gastritis in the elderly,and to provide guidance for the clinical use of the disease.Methods 70 elderly patients with chronic superficial gastritis who were treated in the hospital from June 2015 to June 2016 were randomly divided into control group(35 cases)and study group(35 cases).The patients in the control group were treated with oral lansoprazole,15 mg/time,once a day.The study group was given Jinweitai Capsule on the basis of the control group,0.9 g/time,3 times a day.For 4 weeks.The clinical efficacy of the two groups of patients was observed,and the adverse reactions and the recurrence of treatment for 6 months were compared.Results After treatment,the total effective rate of the study group(91.43%)was significantly higher than that of the control group(71.43%),the difference was statistically significant(χ^2=4.629,P<0.05).The incidence of adverse reactions in the study group(5.71%)was significantly lower than that of the control group(22.86%),the difference was statistically significant(χ^2=4.200,P<0.05);the recurrence rate of the study group at 6 months(3.13%)was significantly lower than that of the control group(20.00%),the difference was statistically significant(χ^2=4.244,P<0.05).Conclusion Lansoprazole combined with Jinweitai in the treatment of chronic superficial gastritis in the elderly can improve the clinical efficacy,control the recurrence rate of the disease,reduce the incidence of adverse reactions,and the safety of medication is higher,and the clinical promotion value is significant.
作者
魏冬梅
汪岩巍
安红军
周晓滨
朱艳萍
WEI Dong-mei;WANG Yan-wei;AN Hong-jun;ZHOU Xiao-bin;ZHU Yan-ping(Digested Division,Section 6,the First Hospital of Qiqihar,Qiqihar,Heilongjiang Province,161000 China)
出处
《系统医学》
2019年第23期138-140,共3页
Systems Medicine
基金
齐齐哈尔市科技局指导项目（SFZD-2019080）
齐齐哈尔市科技局指导项目（SFZD-2017056）
关键词
兰索拉唑
金胃泰
老年慢性浅表性胃炎
临床疗效
不良反应
Lansoprazole
Jinweitai
Elderly chronic superficial gastritis
Clinical efficacy
Adverse reactions
