摘要
目的:探讨儿童外周神经母细胞性肿瘤临床病理因素与预后的相关性。方法:收集119例外周神经母细胞性肿瘤患儿的年龄、性别、发病部位、临床分期、病理类型、核碎裂指数(mitosis karyorrhexis index,MKI)、Ki-67指数、治疗方式以及预后情况,通过绘制Kaplan-Meier生存曲线、进行Log-rank χ^2检验以及Cox回归模型分析,探讨影响患儿预后的相关因素。结果:119例患儿中男72例、女47例,年龄平均28.07个月,生存时间平均48.74个月。单因素分析显示年龄、部位、临床分期、Ki-67指数及治疗方式与预后有一定相关性,多因素分析显示临床分期与治疗方式是预后的独立影响因素(P<0.05)。结论:外周神经母细胞性肿瘤儿童常见且病死率高,尽早诊断、明确分期,并综合检查结果制订合适的治疗方式,对于改善患儿预后具有一定的临床意义。
Objective:To investigate the correlation between clinicopathological factors and prognosis in children’s peripheral neuroblastic tumors.Methods:The age,sex,location,clinical stage,pathological type,mitosis karyorrhexis index(MKI),Ki-67 index,treatment and prognosis of peripheral neuroblastic tumors in 119 cases were collected.Then Kaplan-Meier survival curves were drawn,with the Log-rank χ^2 test and Cox regression model were used to explore the factors that may influence the prognosis of patients.Results:There were 72 boys and 47 girls with an average age of 28.07 months and an average survival time of 48.74 months.Univariate analysis showed that age,location,clinical stage,Ki-67 index and treatment were associated with prognosis.While multivariate analysis showed that clinical stage and treatment were independent prognostic factors(P<0.05).Conclusion:Peripheral neuroblastic tumors,which are common in pediatric patients,usually have a high mortality rate.Early diagnosis and clear staging,combining with appropriate treatments result from comprehensive examinations,may have a certain clinical significance for improving the prognosis of pediatric patients.
作者
方园
王一真
黎绍梅
FANG Yuan;WANG Yizhen;LI Shaomei(Department of Pathology,Anhui Provincial Children’s Hospital,Hefei 230051,China)
出处
《临床与病理杂志》
2019年第12期2727-2732,共6页
Journal of Clinical and Pathological Research
关键词
儿童
外周神经母细胞性肿瘤
临床病理因素
预后
children
peripheral neuroblastic tumor
clinicopathological factor
prognosis
