摘要
目的:探讨红细胞分布宽度(red cell distribution width,RDW)与老年反杓型高血压患者早期肾功能损伤的关系。方法:选取2015年9月至2018年8月首都医科大学附属北京中医医院收治的老年反杓型高血压患者256例作为观察组,年龄匹配的老年非杓型高血压患者89例作为对照组。比较两组患者基线资料及其RDW、肌酐(Cr)、尿素氮、β2微球蛋白(β2-MG)、胱抑素C(CysC)、尿微量白蛋白(microalbuminuria,MAU)及肾小球滤过率(estimated glomerular filtration rate,eGFR),并进一步分析RDW与老年反杓型高血压患者β2-MG,MAU,CysC的关系。结果:观察组RDW,MAU,Cr,尿素氮,β2-MG,CysC高于对照组(P<0.05),而eGFR低于对照组(P<0.05);Pearson相关分析示对照组RDW值与β2-MG(r=0.212,P<0.05),MAU(r=0.357,P<0.05),CysC呈显著正相关(r=0.236,P<0.05);多元线性Logistic回归分析示RDW(OR=1.91,95%CI 1.06~3.19,P=0.03),β2-MG(OR=4.12,95%CI 2.05~8.31,P<0.001),MAU(OR=0.42,95%CI 0.20~0.79,P=0.01)是老年反杓型高血压患者肾损伤的危险因素。结论:RDW是老年反杓型高血压患者早期肾损伤的影响因素,提示其可作为此类患者早期肾功能损伤的独立预测指标。
Objective:To analyze the relationship between red cell distribution width and early renal damage in elderly patients with anti-dipper hypertension.Methods:From September 2015 to August 2018 in Beijing Hospital of Traditional Chinese Medicine,Capital Medical University,a total of 256 elderly patients with anti-dipper hypertension were selected as an observation group,meanwhile 89 old people with non-dipper hypertension were selected as a control group.Baseline of two group and the following index:red cell distribution width,Microalbuminuria(MAU),blood urea nitrogen,creatinine,β2 microglobulin(β2-MG),cystatin C(CysC),glomerular filtration rate were compared between the two groups,and then analyzed the relationship between red cell distribution width and MAU,β2-MG,CysC in elderly patients with anti-dipper hypertension.Results:Red cell distribution width,MAU,blood urea nitrogen,creatinine,β2-MG and CysC of observation group were statistically significantly higher than those of control group(P<0.05),while glomerular filtration rate of observation group was statistically significantly lower than that of control group(P<0.05).Pearson correlation analysis results showed that red cell distribution width was correlated withβ2-MG(r=0.212,P<0.05),MAU(r=0.357,P<0.05),CysC(r=0.236,P<0.05).Multivariate linear regression analysis results showed that red cell distribution width(OR=1.91,95%CI 1.06–3.19,P=0.03),β2-MG(OR=4.12,95%CI 2.05–8.31,P<0.001),MAU(OR=0.42,95%CI 0.20–0.79,P=0.01)were the influencing factors of renal impairment in elderly patients with anti-dipper hypertension.Conclusion:Red cell distribution width is the influencing factor of early renal impairment in elderly patients with anti-dipper hypertension,suggesting that red cell distribution can be used as an indicator for early renal impairment in these patients with anti-dipper hypertension.
作者
姜惠敏
黄立纲
牛芊
张振民
洪艳英
JIANG Huimin;HUANG Ligang;NIU Qian;ZHANG Zhenmin;HONG Yanying(Department of Clinical Laboratory,Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University,Beijing 100010;Department of Clinical Laboratory,First Affiliated Hospital of Tsinghua University,Beijing 100084,China)
出处
《临床与病理杂志》
2019年第12期2773-2779,共7页
Journal of Clinical and Pathological Research
关键词
红细胞分布宽度
反杓型高血压
肾功能损伤
老年
早期
red cell distribution width
anti-dipper hypertension
renal impairment
aged
early
