摘要
肝自噬与非酒精性脂肪性肝病(NAFLD)的发生发展密切联系。在非酒精性单纯性脂肪肝(NAFL)、非酒精性脂肪性肝炎(NASH)阶段肝细胞自噬水平降低;在肝纤维化(HF)阶段,肝星状细胞自噬增强,从而导致疾病的不断发展。因此,研究清楚肝自噬在NAFLD不同时期的变化规律及具体信号通路,有利于对肝组织自噬水平进行调控把握,促使病变减轻。本文通过总结发现不同辨证论治的中药复方对NAFLD不同时期肝自噬有增强或抑制作用,这为NAFLD基础及临床研究提供新的思路。
Autophagy of liver is closely related to the occurrence and development of non-alcoholic fatty liver disease(NAFLD).The autophagy level of hepatocytes decreased in the stage of nonalcoholic simple fatty liver(NAFL)and nonalcoholic steatohepatitis(NASH).In the stage of hepatic fibrosis(HF),autophagy of HSCS increases,this leads to the development of the disease.Therefore,a clear understanding of the change rules and specific signal pathways of liver autophagy in different stages of NAFLD is conducive to the regulation and control of the level of liver autophagy and the alleviation of lesions.In this paper,we find that different traditional Chinese medicine compounds with different syndrome differentiation and treatment can enhance or inhibit liver′s autophagy in different stages of NAFLD,which provides new ideas for basic and clinical research of NAFLD.
作者
谭丽萍
石安华
朱晓松
邓雪
李继晓
陈文慧
TAN Liping;SHI Anhua;ZHU Xiaosong;DENG Xue;LI Jixiao;CHEN Wenhui(School of Basic Medicine,Yunnan University of Chinese Medicine,Yunnan Province,Kunming 650500,China;the Personnel Department,Yunnan University of Chinese Medicine,Yunnan Province,Kunming 650500,China;College of Traditional Chinese Medicine,Yunnan University of Chinese Medicine,Yunnan Province,Kunming 650500,China;Department of Science and Technology,Yunnan University of Chinese Medicine,Yunnan Province,Kunming 650500,China)
出处
《中国医药导报》
CAS
2019年第34期50-53,共4页
China Medical Herald
基金
国家自然科学基金资助项目(81760818)
云南省教育厅科学研究基金项目(2018JS287)
关键词
非酒精性脂肪性肝病
自噬
中药复方
研究进展
Non-alcoholic fatty liver disease
Autophygy
Traditional Chinese medicine compound
Research progress
