摘要
目的:观察茵陈蒿汤加减联合甘草酸二铵、熊去氧胆酸治疗淤胆型肝炎的临床疗效和安全性,为淤胆型肝炎的临床治疗提供用药参考。方法:150例淤胆型肝炎住院患者随机分为对照组75例与观察组75例。对照组患者给予甘草酸二铵和熊去氧胆酸治疗,观察组患者在对照组治疗的基础上给予茵陈蒿汤加减,水煎,早晚分2次温服。两组疗程均为8周。观察两组患者的临床疗效,比较两组治疗前后血清总胆红素(TBIL)、直接胆红素(DBIL)、丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、以及碱性磷酸酶(AKP)、谷氨酰基转移酶(GGT)等指标变化和药品不良反应发生情况。结果:观察组患者总有效率显著高于对照组(P<0.05)。治疗后两组患者TBIL、DBIL、ALT、AST、AKP、GGT等指标水平均较本组治疗前显著下降,且观察组显著低于对照组,差异有统计学意义(P<0.05)。两组患者治疗期间均未见明显不良反应发生。结论:茵陈蒿汤加减联合甘草酸二铵、熊去氧胆酸治疗淤胆型肝炎疗效显著,安全性较好,可以作为临床治疗淤胆型肝炎的有效方法。
Objective:To observe the clinical efficacy and safety of modified Yinchenhao decoction combined with diammonium glycyrrhizinate and ursodeoxycholic acid in the treatment of cholestatic hepatitis to provide reference for clinical treatment of cholestatic hepatitis.Methods:A total of 150 patients with cholestatic hepatitis were divided into the control group(n=75)and the observation group(n=75)according to the random number table.The control group was given diammonium glycyrrhizinate and ursodeoxycholic acid capsules.The observation group was given modified Yinchenhao decoction orally twice a day on the basis of control group.The treatment course was 8 weeks.The clinical efficacy and the adverse drug reactions(ADRs)were observed in 2 groups;and the changes of TBIL,DBIL,ALT,AST,AKP and GGT were compared between them before and after the treatment.Results:The total effective rate of the observation group was significantly higher than that of the control group with statistical significance(P<0.05).After the treatment,the levels of TBIL,DBIL,ALT,AST,AKP and GGT of the 2 groups were significantly lower than those before the treatment,and those of the observation group were significantly lower than those of the control group with statistical significance(P<0.05).No obvious ADR was found in the 2 groups during the treatment.Conclusion:Modified Yinchenhao decoction combined with diammonium glycyrrhizinate and ursodeoxycholic acid is remarkably effective and safe in the treatment of cholestatic hepatitis,which can be used as an effective method for the clinical treatment of cholestatic hepatitis.
作者
杜航
何文生
夏晓影
刘荷蕾
李航
Du Hang;He Wensheng;Xia Xiaoying;Liu Helei;Li Hang(Department of Pharmacy,Chongqing Dazu District People's Hospital,Chongqing 402360,China;Department of Hepatopathy,Chongqing Dazu District People's Hospital,Chongqing 402360,China)
出处
《中国药师》
CAS
2019年第12期2233-2236,共4页
China Pharmacist
基金
重庆市大足区科委科技项目(编号:DZKJ,2014Acc1031)
关键词
淤胆型肝炎
茵陈蒿汤加减
甘草酸二铵
熊去氧胆酸
疗效
安全性
Cholestatic hepatitis
Yinchenhao decoction
Diammonium glycyrrhizinate
Ursodeoxycholic acid
Therapeutic efficacy
Safety
