摘要
目的探讨洛索洛芬钠联合玻璃酸钠关节腔内注射对骨关节炎患者炎症因子及疼痛的影响。方法选取2017年1月至2018年11月成都中医药大学附属医院收治的骨关节炎患者143例,进行回顾性研究,按照治疗方法将患者分为两组:研究组(n=72,行洛索洛芬钠+玻璃酸钠关节腔内注射)和对照组(n=71,行玻璃酸钠关节腔内注射)。观察两组患者的临床疗效、疼痛程度、6 min步行距离、血清炎症因子水平以及骨性关节炎评量表(WOMAC)评分。结果治疗4周后,研究组患者的总有效率(68.05%)高于对照组(47.88%),组间比较差异具有统计学意义(P<0.05);治疗8周后,研究组患者的总有效率(83.33%)高于对照组(64.79%),组间比较差异具有统计学意义(P<0.05)。治疗后,研究组VAS评分为(3.78±1.09)分,对照组为(4.51±1.14)分;研究组6 min步行距离为(132.52±15.47)m,对照组为(97.69±14.19)m,组间比较差异具有统计学意义(P<0.05)。治疗后,研究组血清炎症因子水平为:IL-1β(33.98±5.91)μg/ml、IL-6(7.67±2.69)μg/ml、TNF-α(12.92±3.07)μg/ml;对照组为L-1β(45.69±6.87)μg/ml、IL-6(12.69±3.21)μg/ml、TNF-α(16.45±4.36)μg/ml;各指标组间比较差异具有统计学意义(P<0.05);研究组治疗后WOMAC评分为(32.00±5.39)分,对照组为(35.28±8.36)分,组间比较差异具有统计学意义(P<0.05)。结论洛索洛芬钠联合玻璃酸钠关节腔内注射可改善骨关节炎患者的炎症反应,减轻病痛,提高治疗效果,促进功能恢复,促进患者早日回归家庭和社会。
Objective To investigate the effect of intra-articular injection of loxoprofen sodium and sodium hyaluronate on inflammatory factors and pain in patients with osteoarthritis.Methods 143 patients with osteoarthritis admitted in Affiliated Hospital of Chengdu University of Traditional Chinese Medicine from January 2017 to November 2018 were selected in this retrospective study.They were randomly divided into two groups by random number table method.72 patients in the study group(loxoprofen sodium+sodium hyaluronate intra-articular injection)and71 patients in the control group(sodium hyaluronate intra-articular injection).The clinical efficacy,pain degree,6-minute walking distance,inflammatory factors level and WOMAC osteoarthritis index between the two groups were compared.Results After 4 weeks of treatment,the total effective rate of the study group(68.05%)was higher than that of the control group(47.88%).The difference between the two groups was statistically significant(P<0.05).After 8 weeks of treatment,the total effective rate of the study group(83.33%)was higher than that of the control group(64.79%).The difference between the two groups was statistically significant(P<0.05).After treatment,the VAS score of the study group was(3.78±1.09)and that of the control group was(4.51±1.14).The walking distance of the study group was(132.52±15.47)m in 6 minutes,and that of the control group was(97.69±14.19)m.The difference between the two groups was statistically significant(P<0.05).After treatment,the level of inflammation factors in the study group were as follows:IL-1 beta(33.98±5.91)μg/ml,IL-6(7.67±2.69)μg/ml,TNF-alpha(12.92±3.07)μg/ml,while those in the control group were L-1 beta(45.69±6.87)μg/ml,IL-6(12.69±3.21)μg/ml and TNF-alpha(16.45±4.36)μg/ml.The difference between the two groups was statistically significant(P<0.05).After treatment,the WOMAC score of the study group was(32.00±5.39)and that of the control group was(35.28±8.36).The difference between the two groups was statistically significant(P<0.05).Conclusion Intra-articular injection of loxoprofen sodium combined with sodium hyaluronate can improve the inflammatory reaction,alleviate the pain,improve the therapeutic effect,promote functional recovery and promote the early return of patients to family and society.
作者
易辉
柯洪
刘健佳
刘强
周小力
YI Hui;KE Hong;LIU Jian-jia(Department of Pharmaceutical,Chengdu University of Traditional Chinese Medicine,Chengdu Sichuan 610000,China;Department of Orthopaedics,Chengdu University of Traditional Chinese Medicine,Chengdu Sichuan 610000,China)
出处
《临床和实验医学杂志》
2020年第1期98-102,共5页
Journal of Clinical and Experimental Medicine
基金
四川省科技计划项目(编号:2015JY0159)
关键词
骨关节炎
洛索洛芬钠
玻璃酸钠
炎症因子
疼痛
Osteoarthritis
Loxoprofen sodium
Sodium hyaluronate
Inflammatory factors
Pain
