摘要
目的评价清肺固本汤治疗慢性阻塞性肺疾病(COPD)稳定期的临床疗效。方法回顾分析80例COPD稳定期患者,采用随机数字表法分为治疗组、对照组,各纳入40例病例,对照组应用沙美特罗替卡松粉吸入剂(50 gg/500^ig)治疗,治疗组患者在对照组基础上加用清肺固本汤(枳壳10 g,桔梗10 g,陈皮10 g,法半夏9g,茯苓15g,桑白皮15 g,杏仁10g,黄苓10g,浙贝母15 g,乌贼骨15 g,苏子10g,莱腹子15 g,炒冬瓜仁15g,太子参15g,炒白术10g,炒麦芽30g等),每月为1疗程,连续用药3个疗程。结果评价结果显示,治疗组总有效率(92.50%)显著高于对照组(75.00%)(PV0.05).与治疗前比较,2组治疗后患者单项症状咳嗽、咳痰、气喘、呼吸困难指数、肺功能均有显著差异(P<0.05);2组治疗后组间对比,治疗组患者单项症状咳嗽、咳痰、呼吸困难指数分别为(1.55±1.47)分、(1.45±0.91)分、(1.20±0.76)分、均明显低于对照组(PV0.05),急性加重风险低于对照组(PV0.05),肺功能变化差异无统计学意义(P>0.05)„结论在COPD稳定期,清肺固本汤可能通过改善血管内皮功能障碍,减轻气道炎症反应,从而改善患者咳嗽、咳痰等症状,提高总有效率,并降低急性加重风险。
Objective To evaluate the clinical efficacy of Qingfei Guben decoction in the treatment of stable chronic obstructive pulmonary disease(COPD).Methods The author reviewed and analyzed 80 patients with stable COPD.They were divided into treatment group and control group by random digital table method,each case was included in 40 cases.The control group was treated with salmeterol and fluticasone powder inhalation(50|ig/500(ig),the patients in the group were added Qingfei Guben decoction on the basis of the control group(orange fruit 10 g,platycodon root 10 g,dried tangerine peel 10 g,processed pinellia tuber 9 g,Indian bread 15 g,white mulberry rootbark 15 g,bitter apricot seed 10 g,baical skullcap root 10 g,thunberbg fritillary bulb 15 g,cuttlebone 15 g,perilla fruit 10 g,radish seed 15 g,fried melon kernel 15 g,heterophylly falsestarwort root 15 g,largehead atractylodes rhizome 10 g,genninated barley 30 g,etc.),one course of treatment per month,3 courses of continuous medication.Results The evaluation results showed that the total effective rate of the treatment group(92.50%)was significantly higher than that of the control group (75.00%) (P < 0.05). Compared with before treatment, the patients hadsignificant differences in cough, expectoration, asthma, dyspnea index and lung function after treatment (P < 0.05).After treatment, the patients in the treatment group had single symptom cough, the cough and dyspnea index were(1.55± 1.47), (1.45±0.91), (1.20±0.76), and the risk of acute exacerbation, which were significantly lower than thecontrol group (P < 0.05). There was no significant difference in lung function (P > 0.05). Conclusion In the stablephase of COPD, Qingfei Guben decoction may improve the vascular endothelial dysfunction and reduce the airwayinflammatory response, thereby improving the symptoms of cough, sputum, etc., improving the total effective rate, andreducing the risk of acute exacerbation.
作者
蔡绪明
王志梅
杨栓柱
孙昉昉
张军城
王文
CAI Xuming;WANG Zhimei;YANG Shuanzhu;SUN Fangfang;ZHANG Juncheng;WANG Wen(Department of Lung Disease,Shaanxi Traditional Chinese Medicine Hospital,Xi'an 710000,China)
出处
《吉林中医药》
2019年第12期1613-1616,1620,共5页
Jilin Journal of Chinese Medicine
基金
陕西省中医管理局中医药科研课题（2017ZYPT016）
关键词
慢性阻塞性肺疾病
清肺固本汤
沙美特罗替卡松粉吸入剂
chronic obstructive pulmonary disease
Qingfei Guben decoction
salmeterol and fluticasone powder inhalation
