摘要
目的探讨非洛地平缓释片与硝苯地平控释片治疗高血压的临床疗效,为临床诊疗提供指导。方法选取天津市职业病防治院2017年3月-2019年3月收治60例高血压患者进行研究。按照随机数表法,将患者分为两组,每组30例。观察组给予硝苯地平控释片治疗,对照组给予非洛地平缓释片治疗。观察比较两组患者治疗后临床疗效,不良反应发生率,比较两组患者治疗前后血压与血液流变学指标变化情况。结果观察组患者总有效率(93.33%)与对照组(96.67%)比较无统计学意义(P>0.05)。两组患者治疗后,舒张压、收缩压、24 h平均舒张压、24 h平均收缩压水平均显著低于治疗前,差异有统计学意义(P<0.05),观察组患者治疗前后舒张压、收缩压、24 h平均舒张压、24 h平均收缩压水平与对照组比较无统计学意义(P>0.05)。两组患者治疗后,血浆黏度、全血低切黏度、全血高切黏度、血小板聚集率以及红细胞压积水平均明显低于治疗前,差异有统计学意义(P<0.05),观察组患者治疗前后血浆黏度、全血低切黏度、全血高切黏度、血小板聚集率以及红细胞压积水平与对照组比较无统计学意义(P>0.05)。观察组患者治疗后不良反应发生率为13.33%,对照组为10.00%,二者差异无统计学意义(P>0.05)。结论非洛地平缓释片与硝苯地平控释片均可有效控制高血压的血压水平,不良反应发生率低,安全有效,值得临床推广应用。
Objective To investigate the clinical efficacy of felodipine sustained-release tablets and nifedipine controlled release tablets in the treatment of hypertension,and provide guidance for clinical diagnosis and treatment.Methods Totally 60 patients with hypertension in our hospital from March 2017 to March 2019 were selected for the study.According to the random number table method,the patients were divided into two groups,30 cases in each group.The observation group was treated with nifedipine controlled-release tablets,and the control group was treated with felodipine sustained-release tablets.The clinical efficacy and adverse reaction rate of the two groups were compared and compared.The changes of blood pressure and hemorheology before and after treatment were compared between the two groups.Results The total effective rate(93.33%)of the observation group were not statistically significant compared with the control group(96.67%)(P>0.05).After treatment,the diastolic blood pressure,systolic blood pressure,24 h mean diastolic blood pressure,and 24 h mean systolic blood pressure were significantly lower than before treatment,and the difference was statistically significant(P<0.05),there were no significant differences in the diastolic blood pressure,systolic blood pressure,24 h mean diastolic blood pressure,and 24 h mean systolic blood pressure between the observation group and the control group(P>0.05).After treatment,plasma viscosity,whole blood low-cut viscosity,whole blood high-viscosity,platelet aggregation rate and hematocrit level were significantly lower than before treatment,and the difference was statistically significant(P<0.05),the plasma viscosity,whole blood low-cut viscosity,whole blood high-viscosity,platelet aggregation rate and hematocrit level of the observation group were not significantly different from those of the control group before and after treatment(P>0.05).The incidence of adverse reactions in the observation group were 13.33%after treatment and 10.00%in the control group,there was no significant difference between the two groups(P>0.05).Conclusion Felodipine sustained-release tablets and nifedipine controlled-release tablets can effectively control the blood pressure level of hypertension,the incidence of adverse reactions is low,safe and effective,and it is worthy of clinical application.
作者
张新晖
ZHNAG Xin-hui(Tianjin Vocational Disease Prevention and Treatment Hospital,Tianjin 300011,China)
出处
《医药论坛杂志》
2019年第12期55-58,62,共5页
Journal of Medical Forum
关键词
高血压
非洛地平缓释片
硝苯地平控释片
临床疗效
血压
疗效
Hypertension
Felodipine sustained-release tablets
Nifedipine controlled-release tablets
Clinical efficacy
Blood pressure
Efficacy
