摘要
目的探讨不同放化疗治疗模式对改良根治术后局部晚期乳腺癌患者的疗效。方法选取2013年1月至2015年1月新疆医科大学附属中医医院收治的改良根治术后局部晚期乳腺癌患者300例,根据术后采用的放化疗治疗模式不同分为序贯放化疗组(n=145)和同步放化疗组(n=155)。两组患者均在乳腺癌改良根治术后3周开始进行氟尿嘧啶+表柔比星+环磷酰胺+多西他赛化疗,序贯放化疗组在化疗结束后进行放疗,同步放化疗组在多西他塞化疗阶段进行放疗。比较两组患者的近远期疗效、不良反应以及局部和远处转移情况。结果同步放化疗组整个化疗周期较序贯放化疗组明显缩短[(18.3±1.2)周比(22.6±1.4)周](P<0.01)。同步放化疗组的总缓解率与序贯放化疗组比较差异无统计学意义[76.13%(118/155)比72.41%(105/145)](P>0.05)。序贯放化疗组和同步放化疗组局部复发率比较差异无统计学意义[3.76%(5/133)比2.76%(4/145)](P>0.05),远处转移率比较差异无统计学意义[13.53%(18/133)比11.03%(16/145)](P>0.05)。两组各项不良反应分级(心功能损害除外)比较差异无统计学意义(P>0.05),随访期间无死亡病例。结论同步放化疗可缩短改良根治术后局部晚期乳腺癌患者的治疗周期,患者耐受性好,对局部复发率和远处转移率无显著影响。
Objective To investigate the effect of different radiotherapy and chemotherapy modes on patients with locally advanced breast cancer after modified radical mastectomy.Methods A total of 300 patients with locally advanced breast cancer after modified radical mastectomy in Traditional Chinese Medicine Hospital Affiliated to Xinjiang Medical University from Jan.2013 to Jan.2015 were included in the study and divided into a sequential radiotherapy and chemotherapy group(n=145)and a synchronous radiotherapy and chemotherapy group(n=155)according to the different postoperative treatment methods.Both groups were treated with fluorouracil+epimorubicin+cyclophosphamide+docetaxel chemotherapy starting from 3 weeks after modified radical mastectomy.The sequential group was treated with radiotherapy after the end of chemotherapy,while the synchronous group was treated with radiotherapy at the stage of docetaxel chemotherapy.The short-term and long-term effects,the incidence of adverse reactions,and local and distant metastasis of the two groups were compared.Results The duration of therapy of the synchronous group was significantly shorter than that of the sequential group[(18.3±1.2)week vs(22.6±1.4)week](P<0.01).The overall response rate of the synchronous group was not significantly different from the sequential group[76.13%(118/155)vs 72.41%(105/145)](P>0.05).During the follow-up period,there was no significant difference between the local recurrence rate[3.76%(5/133)vs 2.76%(4/145),P>0.05]and distant metastasis rate[13.53%(18/133)vs 11.03%(16/145),P>0.05]of the two groups.There was no significant difference between the incidence of adverse reactions of the two groups(P>0.05),except for cardiac damage.No deaths occurred during follow-up.Conclusion Synchronous radiotherapy and chemotherapy can shorten the treatment cycle of patients with locally advanced breast cancer after modified radical mastectomy,with good patient tolerance and no significant effect on local and distant metastasis rate.
作者
别克扎提·再孜提汉
陈辉
王薇
耿中利
BIE KE ZHA TI·Zaizitihan;CHEN Hui;WANG Wei;GENG Zhongli(Department Two of General Surgery,Traditional Chinese Medicine Hospital Affiliated to Xinjiang Medical University,Urumqi 830000,China)
出处
《医学综述》
2020年第1期178-182,共5页
Medical Recapitulate
基金
新疆维吾尔自治区自然科学基金(2017D01C165)
关键词
乳腺癌
局部晚期
放化疗模式
预后
改良根治术
Breast cancer
Locally advanced stage
Radiotherapy and chemotherapy mode
Prognosis
Modified radical operation
