摘要
目的探讨阿立哌唑用于治疗利培酮所致女性精神分裂症患者高泌乳素血症的效果。方法本研究选取2017年6月-2019年6月我院收治的70例女性精神分裂症利培酮所致高泌乳素血症患者作为研究对象,随机分为观察组(35例)和对照组(35例);对照组采用利培酮单一药物治疗,观察组采用利培酮+阿立哌唑治疗;对两组血清泌乳素含量、PANSS量表得分及不良反应发生情况进行对比分析。结果治疗前两组血清泌乳素水平比较差异不显著(P>0.05);经治疗对照组血清泌乳素水平无显著变化(P>0.05),观察组血清泌乳素水平显著降低(P<0.05);治疗后观察组血清泌乳素水平显著低于对照组(P<0.05);治疗前及治疗后两组PANSS量表各维度及总评分比较差异均无统计学意义(P>0.05);两组不良反应发生率比较差异不显著(P>0.05)。结论阿立哌唑用于治疗利培酮所致女性精神分裂症患者高泌乳素血症安全有效。
Objective To investigate the effect of aripiprazole in the treatment of hyperprolactinemia in female schizophrenic patients induced by risperidone.Methods Seventy female schizophrenic patients with risperidone-induced hyperprolactinemia in our hospital from June 2017 to June 2019 were randomly divided into observation group(35 cases)and control group(35 cases).The control group was treated with risperidone alone,while the observation group was treated with risperidone+aripiprazole.The serum prolactin content,PANSS score and adverse reactions were compared and analyzed.Results There was no significant difference in serum prolactin level between the two groups before treatment(P>0.05).There was no significant change in serum prolactin level in the control group after treatment(P>0.05).The serum prolactin level in the observation group decreased significantly(P<0.05).The serum prolactin level in the observation group was significantly lower than that in the control group after treatment(P<0.05).There was no significant difference in the dimensions and total scores of PANSS scale between the two groups after treatment(P>0.05),and there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Aripiprazole is safe and effective in the treatment of hyperprolactinemia in female schizophrenic patients induced by risperidone.
作者
苏晓东
SU Xiaodong(Department of Psychiatry,Xianyue Hospital,Xiamen Fujian 361000,China)
出处
《中国卫生标准管理》
2019年第24期72-75,共4页
China Health Standard Management
