摘要
目的探究不同血浆置换方式在免疫性疾病及肾移植急性排斥反应中的应用,为临床实践提供理论依据。方法本研究纳入2016年4月至2018年3月西安市中心医院收治的100例免疫性疾病及肾移植急性排斥反应患者,分为对照组和研究组,每组各50例,对照组给予单重滤过血浆净化,研究组给予双重滤过血浆置换,对比两组患者生化指标、治疗情况、不良反应、预后情况,进行统计学分析。结果研究组治疗后的血浆免疫球蛋白G和抗肾小球基底膜抗体水平低于对照组,差异具有统计学意义(P<0.05)。研究组不良反应发生率明显低于对照组,差异具有统计学意义(P<0.05)。研究组患者住院时间、治疗费用均优于对照组,差异具有统计学意义(P<0.05)。研究组患者肾功能恢复率明显高于对照组,差异具有统计学意义(P<0.05)。结论免疫性疾病及肾移植急性排斥反应患者实施选择性双重滤过血浆净化,有效改善血液免疫球蛋白G与抗肾小球基底膜抗体水平,缩短治疗时间,提高治疗有效率,降低不良反应,治疗效果显著。
Objective To investigate the application of selective single and double filtration plasmapheresis in immune diseases and acute rejection of renal transplantation,and to provide theoretical basis for clinical practice.Methods A total of 100 patients with immune diseases and acute rejection of renal transplantation,treated in Xi’an Central Hospital from April 2016 to March 2018,were enrolled in this study and divided into control group(n=50)and study group(n=50)The control group was given single-filtration plasmapheresis,and the study group was given double filtration plasmapheresis.The biochemical indexes,treatment,adverse reactions and prognosis of the two groups were compared.Results The plasma IgG and anti-glomerular basement membrane(GBM)antibody levels in the study group were lower than those in the control group after treatment,with statistically significant difference(P<0.05).The incidence of adverse reactions in the study group was significantly lower than that in the control group,with statistically significant difference(P<0.05).The hospitalization time and treatment cost of the patients in the study group had advantage over the control group,with statistically significant difference(P<0.05).The effective rate of renal function recovery in the study group was significantly higher than that in the control group,with statistically significant difference(P<0.05).Conclusions Selective double filtration plasmapheresis is performed in patients with immune diseases and acute rejection of renal transplantation,which can effectively improve the level of immunoglobulin IgG and anti-GBM antibody,shorten the treatment time,improve the effective rate of treatment and reduce the adverse reactions.The therapeutic effect is remarkable.
作者
赵燕
雷洁
李苏童
戴维
ZHAO Yan;LEI Jie;LI Su-tong;DAI Wei(Department of Nephrology,Xi’an Central Hospital,Xi’an 710003,China)
出处
《临床肾脏病杂志》
2020年第1期47-50,共4页
Journal Of Clinical Nephrology
基金
陕西省社会发展科技攻关项目(2016SF-224)
关键词
单重滤过血浆净化
双重滤过血浆净化
免疫性疾病
肾移植
排斥反应
Single filtration plasmapheresis
Double filtration plasmapheresis
Immune disease
Kidney transplantation
Rejection
