摘要
目的探讨急性一氧化碳中毒迟发性脑病(DEACMP)的危险因素。方法纳入2015年1月1日至2018年10月1日四川省人民医院收治的急性一氧化碳中毒(ACMP)患者194例,根据是否发生DEACMP,分为迟发性脑病组(DE组)与非迟发性脑病组(NDE),比较两组患者的基本信息、既往病史、实验室指标,分析发生DEACMP的危险因素。结果194例ACMP患者中64例发生DEACMP,两组患者年龄、性别、昏迷与否、昏迷时间、高血压患病率、C反应蛋白(CRP)、D-二聚体(D dimer)等指标比较,差异有统计学意义(P<0.05),糖尿病患病率、血清同型半胱氨酸(Hcy)、谷草转氨酶(AST)、乳酸脱氢酶(LDH)、肌酸激酶(CK)、白细胞(WBC)等指标比较,差异无统计学意义(P>0.05),多因素Logistic回归分析表明年龄(P=0.005)、昏迷时间(P<0.001)、D dimer(P=0.01)是DEACMP发病的独立危险因素。结论年龄越大、昏迷时间越长、早期D dimer升高的ACMP患者发生DEACMP的风险将增高。
Objective To explore the risk factors of delayed encephalopathy in patients with acute carbon monoxide poisoning(DEACMP).Methods One hundred and ninety-four patients with acute carbon monoxide poisoning(ACMP)admitted to Sichuan Provincial People's Hospital from January 1,2015 to October 1,2018 were selected.According to the occurrence of DEACMP,they were divided into delayed encephalopathy group(DE group)and non-delayed encephalopathy group(NDE group).The basic information,history and laboratory indicators of the two groups were compared.The risk factors of DEACMP were analyzed.Results Of the 194 patients with ACMP,64 patients had DEACMP.There were significant differences in age,sex,coma or not,coma time,prevalence of hypertension,C-reactive protein(CRP)and D dimmer between the two groups(P<0.05).There were no significant differences in diabetes prevalence,serum homocysteine(HCY),alanine aminotransferase(AST),lactate dehydrogenase(LDH),creatine kinase(CK),and leukocyte(WBC).Multivariate logistic regression analysis showed that age(P=0.005),coma time(P<0.001),and D-dimmer(P=0.01)were independent risk factors for delayed encephalopathy.Conclusion The older age,the longer of time of the coma,and the earlier increased level of the D dimmer are associated with higher risk of DEACMP in ACMP patients.
作者
吴薇
杨卜凡
秦晓洪
曾宪容
WU-Wei;YANG Bu-fan;QIN Xiao-hong;ZENG Xian-rong(Southwest Medical University,Luzhou 646000,China;Mianyang Central Hospital,Mianyang 621000,China;Center of Hyperbaric Oxygen Therapy,Sichuan Academy of Medical Science&Sichuan People's Hospital,Chengdu 610072,China)
出处
《实用医院临床杂志》
2020年第1期145-147,共3页
Practical Journal of Clinical Medicine
关键词
急性一氧化碳中毒
迟发性脑病
危险因素
预测
Acute carbon monoxide poisoning:Delayed encephalopathy
Risk factors:Forecast
