摘要
目的观察重组人表皮生长因子(recombinant human epidermal growth factor,EGF)对雀斑激光术后皮肤创面的修复效果及安全性。方法选择我院2014年9月至2015年6月接受雀斑激光治疗的60例患者,采用随机数字表法分为试验组和对照组各30例;两组患者均行相同疗程的激光治疗,术后及观察期间,试验组使用EGF面膜,对照组使用金霉素软膏,记录两组患者疼痛、水肿出现情况及创面结痂、愈合时间,并随访至术后3月评定治疗效果。结果两组患者术后均未出现面部水肿,试验组的疼痛时间、结痂时间、愈合时间均小于对照组,差异有统计学意义(P <0. 05)。两组治疗有效率比较,差异无统计学意义(P> 0. 05)。随访至术后3月,两组患者均未出现创面感染、永久性色素改变、瘢痕形成等不良反应。结论 EGF可用于改善雀斑激光术后面部疼痛,减轻红斑等不良反应,促进皮肤创面快速修复,缩短创面愈合时间,疗效确切,是一种安全有效的激光术后修复手段。
Objective To observe the efficacy and safety of recombinant human epidermal growth factor( rh EGF) in repairing wounds after freckle laser surgery.Methods Sixty patients with freckles laser treatment in our hospital from September 2014 to June2015 were randomly divided into experimental or control group,30 in each group.The two groups were treated with the same course of laser treatment.After the operation and observation period,the experimental group used rh EGF mask,while the control group received chlortetracycline ointment.The pain,edema and wound scab and healing time of the two groups were recorded. The patients were followed-up for 3 months after surgery to evaluate the efficacy of treatment.Results There was no facial edema in the two groups.The pain time,crusting time and healing time of the experimental group were shorter than those of the control group( P < 0. 05).There was no significant difference in treatment efficiency between the two groups( P > 0. 05).During the 3 months of follow-up after surgery,no adverse reactions such as wound infection,permanent pigmentation,and scar formation occurred in either group.Conclusion The recombinant human epidermal growth factor can be used to improve the facial pain after freckle laser surgery,reduce the adverse reactions such as erythema,promote the rapid repair of skin wounds,shorten the wound healing time,and have exact curative effect. It is a safe and effective laser repair method.
作者
张楠
ZHANG Nan(Sichuan Academy of Medical Sciences&Sichuan Provincial People’s Hospital,Chengdu 60072,China)
出处
《实用医院临床杂志》
2020年第1期174-176,共3页
Practical Journal of Clinical Medicine
关键词
重组人表皮生长因子
雀斑
激光术后
Recombinant human epidermal growth factor
Freckles
Laser surgery
