摘要
中枢神经系统疾病治疗药物需通过血脑屏障进入脑组织发挥作用。在高原低氧环境下,血脑屏障组织结构中的紧密连接蛋白、星型胶质细胞和内皮细胞上的转运蛋白、内皮细胞上的ATP发生变化,同时血脑屏障通透性增加。这些变化是高原地区中枢神经系统疾病患者的合理用药的重要参考。本文就高原低氧对血脑屏障结构及其药物通透性影响的研究进展作一综述。
Drugs for the treatment of central nervous system diseases need to enter the brain tissue through the blood-brain barrier to function.In high altitude hypoxic environment,there are changes in tight junction proteins of blood-brain barrier tissue structure,transporters in astrocytes and endothelial cells and ATP in endothelial cells;at the same time the permeability of the blood-brain barrier is increased.These changes are an important reference for rational drug use in patients with central nervous system disease in the plateau region.This article reviews the research progress on the effects of plateau hypoxia on the structure of the blood-brain barrier and related drug permeability.
作者
丁怡丹
李文斌
王荣
张建春
DING Yidan;LI Wenbin;WANG Rong;ZHANG Jianchun(Key Laboratory of Plateau Environmental Damage Prevention,the 940th Hospital of PLA Joint Logistics Support Force,Lanzhou 730050,China;School of Pharmacy,Lanzhou University,Lanzhou 730000,China;Department of Pharmacy,First Hospital of ChinesePeople's Liberation Army,Lanzhou 730000,China)
出处
《浙江大学学报（医学版）》
CAS
CSCD
北大核心
2019年第6期668-673,共6页
Journal of Zhejiang University(Medical Sciences)
基金
国家自然科学基金(81673508)
关键词
中枢神经系统疾病
血脑屏障
高海拔
高原病
缺氧
脑/病理生理学
生物转运
综述
Central nervous system diseases
Blood-brain barrier
Altitude
Altitude sickness
Hypoxia
brain/physiopathology
Biological transport
Review
