摘要
目的探讨重组人干扰素α-1b治疗小儿水痘的效果。方法选取2017年1月~2018年12月我院收治的80例水痘患儿作为研究对象,根据随机数字表法将其分为治疗组及对照组,每组各40例。对照组患儿采用常规治疗,治疗组患儿在对照组的治疗基础上加用重组人干扰素α-1b进行治疗。比较两组患儿的治疗总有效率、发热消退时间、皮疹结痂时间、瘙痒缓解时间、住院时间及并发症发生情况。结果治疗组患儿的治疗总有效率高于对照组,差异有统计学意义(P<0.05);治疗组患儿的发热消退时间、皮疹结痂时间、皮疹瘙痒缓解时间及住院时间均短于对照组,差异有统计学意义(P<0.05);两组患儿的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论重组人干扰素α-1b治疗小儿水痘的临床效果良好,临床使用方便、安全、不良反应少,值得临床进一步推广应用。
Objective To observe the effect of Recombinant Human Interferonα-1b in the treatment of infantile varicella.Methods A total of 80 cases of children with varicella admitted to our hospital from January 2017 to December 2018 were selected as objects of study.The children were divided into control group and treatment group according to random number table method,40 cases in each group.The children in the control group were treated with conventional treatment,while the children in the treatment group were treated with Recombinant Human Interferonα-1b on the basis of the control group.The total effective rate,fever regression time,rash scab formation time,itch relief time,hospitalization time and complications were compared between the two groups.Results The total effective rate of the treatment group was higher than that of the control group,the difference was statistically significant(P<0.05).The fever regression time,rash scab formation time,itch relief time and hospitalization time in the treatment group were shorter than those in the control group,the differences were statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Recombinant Human Interferonα-1b is effective in the treatment of varicella in children.It is convenient,safe and has fewer adverse reactions.It is worthy of further clinical application.
作者
周洁雯
ZHOU Jie-wen(Department of Pediatrics,the Eighth People′s Hospital of Guangzhou City,Guangdong Province,Guangzhou510000,China)
出处
《中国当代医药》
2019年第36期145-148,共4页
China Modern Medicine
关键词
水痘
儿童
重组人干扰素Α-1B
疗效
Varicella
Children
Recombinant Human Interferonα-1b
Curative effect
