摘要
目的探讨妊娠期甲状腺功能减退症与妊娠期糖尿病(GDM)孕妇的甲状腺功能及血糖的变化。方法选取宁夏医科大学总医院2017年1月至2018年12月就诊的单纯妊娠期糖尿病孕妇(GDM组)103例、GDM合并甲状腺功能减退症孕妇(GDM合并甲减组)155例以及单纯甲状腺功能减退症孕妇(甲减组)117例,比较3组孕妇的血糖水平及甲状腺功能的变化。结果GDM合并甲减组患者空腹血糖、服糖后1、2 h血糖及糖化血红蛋白水平均高于GDM组(P均<0.05)。GDM合并甲减组患者血清促甲状腺素(TSH)水平、甲状腺过氧化物酶抗体(TPOAb)阳性率均高于甲减组(P均<0.05),游离T3(FT3)、游离T4(FT4)水平均低于甲减组(P均<0.05)。相关性分析结果显示,155例GDM合并甲减组患者的血清TSH和糖化血红蛋白呈负相关(r=-0.423,P=0.021)。结论妊娠期同时合并GDM和甲减的孕妇,其血糖水平和甲状腺功能可互相影响。
Objective To study the changes of thyroid function and blood sugar in pregnant women with gestational diabetes mellitus(GDM).Methods Total 103 pregnant women with GDM,155 pregnant women with GDM and hypothyroidism and 117 pregnant women with hypothyroidism were selected from General Hospital of Ningxia Medical University from January 2017 to December 2018.The changes of blood glucose level and thyroid function in the three groups were compared.Results The levels of fasting blood glucose,blood glucose and HbA1c in GDM group were higher than those in GDM group(P all<0.05).The levels of TSH and TPOAb in GDM patients with hypothyroidism group were higher than those in hypothyroidism group(P all<0.05),and free T3(FT3)and free T4(FT4)were lower than those in hypothyroidism group(P all<0.05).The results of correlation analysis showed that there was a negative correlation between TSH and HbA1c in 155 GDM patients with hypothyroidism(r=-0.423,P=0.021).Conclusion Hypothyroidism during pregnancy is closely related to gestational diabetes mellitus.
作者
马淑琴
纳娟
孙媛
范蓓
MA Shuqin;NA Juan;SUN Yuan;FAN Bei(Department of Obstetric,the General Hospital of Ningxia Medical University,Yinchuan750004,China)
出处
《宁夏医科大学学报》
2019年第11期1135-1138,共4页
Journal of Ningxia Medical University
基金
宁夏自然科学基金(NZ15173)
关键词
甲状腺功能减退症
妊娠期糖尿病
血糖水平
甲状腺功能
hypothyroidism during pregnancy
gestational diabetes mellitus
level of blood glucose
function of thyroid
