摘要
目的探讨重复经颅磁刺激对酒依赖患者稽延性戒断症状与执行功能的影响。方法选取2015年3月~2018年6月我院收治的66例酒依赖患者为研究对象,采用随机数字表法将患者分为对照组与观察组,各33例。对照组常规治疗,观察组在对照组治疗基础上加行重复经颅磁刺激治疗,比较两组患者稽延性戒断症状与执行功能变化情况、临床治疗效果及不良反应。结果两组患者治疗前稽延性戒断症状各指标评分数据比较,差异无统计学意义(P>0.05);治疗3周、6周后观察组HAMD、HAMA、PSQI评分明显低于对照组(P<0.05);两组患者治疗前总应答次数、正确次数、完成分类数指标评分比较,差异无统计学意义(P>0.05);治疗3周、6周后,观察组总应答次数评分下降,低于对照组(P<0.05);正确次数、完成分类数评分上升,高于对照组(P<0.05);观察组治疗总有效率(90.91%)明显高于对于对照组(69.70%)(P<0.05);两组患者治疗过程中均未发生明显不良反应。结论重复经颅刺激治疗酒依赖患者,可以有效改善患者稽延性戒断症状如抑郁、焦虑、睡眠质量,且能够明显提升患者执行功能,疗效显著,安全性高。
Objective To explore the effects of repeated transcranial magnetic stimulation on protracted withdrawal symptoms and executive function of alcohol-dependent patients.Methods 66 patients with alcohol dependence treated in our hospital from March 2015 to June 2018 were enrolled and divided into the control group with 33 patients and the observation group with 33 patients using the random number table method.Regular treatment was conducted in the control group,on the basis of which additional repeated transcranial magnetic stimulation therapy was carried out in the observation group.Changes of protracted withdrawal symptoms and executive function,clinical treatment effects and adverse reactions were compared between the two groups.Results Before treatment,no statistically significant differences were found in the scores evaluating various indicators of protracted withdrawal symptoms between the two groups(P>0.05).However,HAMD,HAMA and PSQI scores in the observation group were significantly lower than those in the control group after 3 weeks and 6 weeks of treatment(P<0.05).No statistically significant differences were seen in the scores of the total number of responses,the number of correct times and the number of accomplished classification between the two groups before treatment(P>0.05).After 3 weeks and 6 weeks of treatment,the scores of the total numbers of responses were decreased in the observation group and lower than those in the control group,and the scores of correct times and times of accomplished classification were increased and higher than those in the control group(P<0.05).The total treatment effective rate in the observation group(90.91%)was significantly higher than that in the control group(69.70%)(P<0.05).Furthermore,no obvious adverse reactions were observed during the treatment in either group.Conclusion Repeated transcranial stimulation can effectively improve the symptoms of protracted withdrawal symptoms in the alcohol-dependent patients,such as depression,anxiety and sleep quality,and can significantly improve the executive function of patients,with distinct efficacy and high safety.
作者
梁胤
许学明
庞军委
LIANG Yin;XU Xueming;PANG Junwei(Department of Psychiatry,Taizhou Second People's Hospital in Zhejiang Province,Tianzhou 317200,China)
出处
《中国现代医生》
2019年第34期4-7,13,共5页
China Modern Doctor
基金
浙江省医药卫生科技计划项目(2019KY780)
关键词
重复经颅磁刺激
酒依赖
稽延性戒断症状
执行功能
威斯康星卡片分类测验
Repeated transcranial magnetic stimulation
Alcohol dependence
Protracted withdrawal symptoms
Executive function
Wisconsin card sorting test