摘要
目的探讨PCT(降钙素原,Procalcitonin)在诊断颅底骨折合并颅内感染中的临床价值。方法选择2016年1月~2018年12月在我院诊断治疗的颅底骨折患者60例的临床资料进行回顾性分析。其中30例患者合并颅内感染,为颅内感染组,30例未发生颅内感染,为无颅内感染组。比较两组入院时PCT、白细胞计数、中性粒细胞百分比水平。比较颅内感染组患者入组时、确认感染时以及出院时PCT、白细胞计数、中性粒细胞百分比水平。分析入院时、确诊时PCT对颅底骨折合并颅内感染的辅助诊断价值。结果(1)入院时颅内感染组PCT水平显著高于无颅内感染组(P<0.05)。(2)确认感染时,颅内感染组PCT水平、白细胞计数、中性粒细胞计数显著高于入院时(P<0.05)。(3)PCT辅助诊断颅底骨折患者颅内感染的AUC为0.989。以1.0μg/L作为界值,敏感度为83.3%,特异度为93.3%。(4)入院时PCT预测颅底骨折合并颅内感染的AUC为0.667。以0.8μg/L作为界值,敏感度为53.3%,特异度为83.3%。结论颅底骨折合并颅内感染的患者在入院时就存在PCT水平升高的情况,在确诊感染时显著升高。确诊时PCT对颅底骨折合并颅内感染的患者具有较好的辅助诊断价值。
Objective To investigate the clinical value of PCT(procalcitonin)in the diagnosis of skull base fracture complicated with intracranial infection.Methods The clinical data of 60 patients with skull base fracture diagnosed and treated in our hospital from January 2016 to December 2018 were retrospectively analyzed.Among them,30 patients with intracranial infection were the skull base infection group,30 cases without intracranial infection were non-intracranial infection group.The PCT,white blood cell count,and neutrophil percentage levels in skull base infection group were compared when entering the group,confirming the infection,and at the time of discharge.The diagnostic value of PCT in skull base fracture combined with intracranial infection at the time of admission and diagnosis was analyzed.Results(1)The PCT level of the skull base infection group was significantly higher than that of the non-intracranial infection group(P<0.05).(2)When the infection was confirmed,the PCT level,white blood cell count and neutrophil count in the intracranial infection group were significantly higher than those at the time of admission(P<0.05).(3)The AUC of PCT assisted diagnosis of intracranial infection in patients with skull base fracture was 0.989.With 1.0μg/L as the cut-off value,the sensitivity was 83.3%and the specificity was 93.3%.(4)The AUC of the PCT for predicting skull base fracture combined with intracranial infection at admission was 0.667.With a boundary value of 0.8μg/L,the sensitivity was 53.3%and the specificity was 83.3%.Conclusion Patients with skull base fractures combined with intracranial infection have elevated PCT levels at admission and the PCT is significantly elevated at the time of diagnosis.At the time of diagnosis,PCT has a good diagnostic value for patients with skull base fracture and intracranial infection.
作者
何婷
邵高峰
HE Ting;SHAO Gaofeng(Department of Surgery,Zhuji People's Hospital in Zhejiang Province,Zhuji311800,China)
出处
《中国现代医生》
2019年第35期27-30,共4页
China Modern Doctor
基金
浙江省医药卫生科技计划项目（2016KYB314）
关键词
PCT
颅底骨折
颅内感染
白细胞计数
中性粒细胞百分比
PCT
Skull base fracture
Intracranial infection
White blood cell count
Neutrophil percentage
